Publications from the Department of Biomedical and Pharmaceutical Sciences faculty at the University of Rhode Island.

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Submissions from 2020

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Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice, Liya Li, Hang Ma, Tingting Liu, Zhanjun Ding, Wei Lu, Qiong Gu, Yu Mu, Jun Xu, Navindra P. Seeram, Xueshi Huang, and Jialin Xu

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Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes, Chang Liu, Hao Guo, Joel A. A. Dain, Yinsheng Wan, Xing Hua Gao, Hong Duo Chen, Navindra P. Seeram, and Hang Ma

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Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes, Chang Liu, Hang Ma, Angela L. Slitt, and Navindra P. Seeram

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Inhibitory Effects of Skin Permeable Glucitol-core Containing Gallotannins from Red Maple Leaves on Elastase and their Protective Effects on Human Keratinocytes, Chang Liu, Yiming Xu, Riley D. Kirk, Huifang Li, Dongli Li, Nicholas A. DaSilva, Matthew Bertin, Navindra P. Seeram, and Hang Ma

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Guavinoside B from: Psidium guajava alleviates acetaminophen-induced liver injury via regulating the Nrf2 and JNK signaling pathways, Yuanyuan Li, Jialin Xu, Dongli Li, Hang Ma, Yu Mu, Xueshi Huang, and Liya Li

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Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice, Emily Marques, Marisa Pfohl, Adam Auclair, Rohitash Jamwal, Benjamin J. Barlock, Ferass M. Sammoura, Michael Goedken, Fatemeh Akhlaghi, and Angela L. Slitt

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Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly, Danielle J. McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T. Clements, and Gaurav Choudhary

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Isolation of Isotrichophycin C and Trichophycins G–I from a Collection of Trichodesmium thiebautii, Kelly M. McManus, Riley D. Kirk, Christopher W. Via, James S. Lotti, Alexandre F. Roduit, Roberta Teta, Silvia Scarpato, Alfonso Magoni, and Matthew Bertin

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Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation, Joshua Owen, Eloise Thomas, Jyothi Menon, Michael Gray, Irini Skaripa-Koukelli, Martin R. Gill, Sheena Wallington, Rebecca L. Miller, Katherine Vallis, and Robert Carlisle

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Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers, Nikhil Pandey, Jyothi Menon, Masaya Takahashi, Jer-Tsong Hsieh, Jian Yang, Kytai T. Nguyen, and Aniket S. Wadajkar

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Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1, Dominique L. Popescu, William Van Nostrand, and John K. Robinson

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Histological-based stainings using free-floating tissue sections, Emily M. Potts, Giuseppe Coppotelli, and Jaime M. Ross

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Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model, Lisa S. Robison, Nikita Francis, Dominique L. Popescu, Maria E. Anderson, Joshua Hatfield, Feng Xu, Brenda J. Anderson, William Van Nostrand, and John K. Robinson

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Phenolic-enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity, Jie Sheng, Chang Liu, Sophia Petrovas, Yinsheng Wan, Hong Duo Chen, Navindra P. Seeram, and Hang Ma

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Retinal Imaging in Alzheimer's and Neurodegenerative Diseases, Peter J. Snyder, Jessica Alber, Clemens Alt, Lisa J. Bain, Brett E. Bouma, Femke H. Bouwman, Delia Cabrera DeBuc, Melanie C.W. Campbell, Maria C. Carrillo, Emily Y. Chew, M. Francesca Cordeiro, Michael R. Dueñas, Brian M. Fernández, Maya Koronyo-Hamaoui, Chiara La Morgia, Roxana O’Carare, Srinivas R. Sadda, Peter van Wijngaarden, and Heather M. Snyder

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Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy, Preston R. Steele, Clarissa Fantin Cavarsan, Lisa Dowaliby, Megan Westefeld, Natallia Katenka, Alexander Drobyshevsky, Monica A. Gorassini, and Katharina A. Quinlan

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Barringtogenol c-type triterpenoid saponins from the stem bark of Norway maple (acer platanoides), Wen Xu, Lu Zhang, Raed Omar, Wei Liu, Zhengxi Wei, Zengguang Zhang, Yu Mu, Navindra P. Seeram, Xueshi Huang, Hang Ma, and Liya Li

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Dysregulation of bile acids increases the risk for preterm birth in pregnant women, Sangmin You, Ai-Min Cui, Syed F. Hashmi, Xinmu Zhang, Christina Nadolny, Yuan Chen, Qiwen Chen, Xin Bush, Zachary Hurd, Winifer Ali, Gang Qin, and Ruitang Deng

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Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface, Yiwen Zhao, Zhuofan Li, Xiaoyue Zhu, Yan Cao, and Xinyuan Chen

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Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy, Xiaoyue Zhu, Joshua Hatfield, Joseph K. Sullivan, Feng Xu, and William Van Nostrand

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Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats, Xiaoyue Zhu, Feng Xu, Michael D. Hoos, Hedok Lee, Helene Benveniste, and William Van Nostrand

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Copper Accumulation and the Effect of Chelation Treatment on Cerebral Amyloid Angiopathy Compared to Parenchymal Amyloid Plaques, Xiayoue Zhu, Tiffany W. Victor, Ashwin Ambi, Joseph K. Sullivan, Joshua Hatfield, Feng Xu, Lisa M. Miller, and William E. Van Nostrand

Submissions from 2019

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Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma, Sravani Adusumalli, Rohitash Jamwal, Lorenzo Leggio, and Fatemeh Akhlaghi

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Role of molybdenum-containing enzymes in the biotransformation of the novel ghrelin receptor inverse agonist PF-5190457: A reverse translational bed-to-bench approachs, Sravani Adusumalli, Rohitash Jamwal, R. Scott Obach, Tim F. Ryder, Lorenzo Leggio, and Fatemeh Akhlaghi

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White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities, Jessica Alber and et al

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Biological Evaluation of DNA Biomarkers in a Chemically Defined and Site-Specific Manner, Ke Bian, James C. Delaney, Xianhao Zhou, and Deyu Li

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DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro, Ke Bian, Stefan AP Lenz, Qi Tang, Fangyi Chen, Rui Qi, Marco Jost, Catherine L. Drennan, John M. Essigmann, Stacey D. Wetmore, and Deyu Li

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Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol, Nicholas Brotzman, Yiming Xu, Allison Graybill, Alexander Cocolas, Andrew Ressler, Navindra P. Seeram, Hang Ma, and Geneive E. Henry

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Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA, Ang Cai, Ke Bian, Fangyi Chen, Qi Tang, Rachel Carley, Deyu Li, and Bongsup P. Cho

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Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2, Fangyi Chen, Qi Tang, Hang Ma, Ke Bian, Navindra P. Seeram, and Deyu Li

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Downregulating NF-κB signaling pathway with triterpenoids for attenuating inflammation:: In vitro and in vivo studies, Min Chen, Ying Qin, Hang Ma, Xi Zheng, Renping Zhou, Shili Sun, Yiqi Huang, Qing Duan, Wenfeng Liu, Panpan Wu, Xuetao Xu, Zhaojun Sheng, Kun Zhang, and Dongli Li

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Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro, Nicholas A. DaSilva, Pragati P. Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H. Zawia, Angela L. Slitt, and Navindra P. Seeram

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Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future, Dinesh Dhamecha, Rachel Movsas, U. Sano, and Jyothi U. Menon

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Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes, Nicole E. James, Lindsey Beffa, Matthew T. Oliver, Ashley D. Borgstadt, Jenna B. Emerson, Clinton O. Chichester, Naohiro Yano, Richard N. Freiman, Paul A. DiSilvestro, and Jennifer R. Ribeiro

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Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins, Nicole E. James, Evelyn Cantillo, Naohiro Yano, Clinton O. Chichester, Paul A. DiSilvestro, Virginia Hovanesian, R. Shyama Prasad Rao, Kyukwang K. Kim, Richard G. Moore, Nagib Ahsan, and Jennifer R. Ribeiro

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Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6, Nicole E. James, Matthew T. Oliver, Jennifer R. Ribeiro, Evelyn Cantillo, Rachel B. Rowswell-Turner, Kyu-Kwang Kim, Clinton O. Chichester, Paul A. DiSilvestro, Richard G. Moore, Rakesh K. Singh, Naohiro Yano, and Ting C. Zhao

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Polyphenol Microbial Metabolites Exhibit Gut and Blood–Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation, Shelby L. Johnson, Riley D. Kirk, Nicholas A. DaSilva, Hang Ma, Navindra P. Seeram, and Matthew Bertin

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Scaffold-based lung tumor culture on porous PLGA microparticle substrates, Aneetta E. Kuriakose, Wenjing Hu, Kytai T. Nguyen, and Jyothi Menon

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Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes, Chang Liu, Hao Guo, Nicholas A. DaSilva, Dongli Li, Kun Zhang, Yinsheng Wan, Xing Hua Gao, Hong Duo Chen, Navindra P. Seeram, and Hang Ma

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New Acylated Phenolic Glycosides with ROS-Scavenging Activity from Psidium guajava Leaves, Yuanyuan Li, Dongli Li, Qi An, Hang Ma, Yu Mu, Wenjun Qiao, Zengguang Zhang, Jingsheng Zhang, Xueshi Huang, and Liya Li

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Antagonism of Quorum Sensing Phenotypes by Analogs of the Marine Bacterial Secondary Metabolite 3-Methyl-N-(2′-Phenylethyl)-Butyramide, Susan M. Meschwitz, Margaret E. Teasdale, Ann Mozzer, Nicole Martin, Jiayuan Liu, Stephanie Forschner-Dancause, and David C. Rowley

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Draft Genome Sequence of the Putative Marine Pathogen Thalassobius sp. I31.1, Hilary J. Ranson, Jason LaPorte, Edward Spinard, Andrei Y. Chistoserdov, Marta Gomez-Chiarri, David R. Nelson, and David C. Rowley

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Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy, Lisa S. Robinson, Dominique L. Popescu, Maria E. Anderson, Nikita Francis, Joshua Hatfield, Joseph K. Sullivan, Steven I. Beigelman, Feng Xu, Brenda J. Anderson, William E. Van Nostrand, and John K. Robinson

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Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016, Anitha Saravanakumar, Armin Sadighi, Rachel Ryu, and Fatemeh Akhlaghi

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Enhancement of macrophage uptake via phosphatidylserine-coated acetalated dextran nanoparticles, Nishan K. Shah, Sweta K. Gupta, Zimeng Wang, and Samantha A. Meenach

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Bacterial Community Dynamics in an Oyster Hatchery in Response to Probiotic Treatment, Rebecca J. Stevick, Saebom Sohn, Tejashree H. Modak, David R. Nelson, David C. Rowley, Karin Tammi, Roxanna Smolowitz, Kathryn Markey Lundgren, Anton F. Post, and Marta Gomez-Chiarri

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Pectic Oligosaccharides from Cranberry Prevent Quiescence and Persistence in the Uropathogenic Escherichia coli CFT073, Jiadong Sun, Robert W. Deering, Zhiyuan Peng, Laila Najia, Christina Khoo, Paul S. Cohen, Navindra P. Seeram, and David C. Rowley

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Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High-Fat-Diet-Fed Mice, Jialin Xu, Tingting Liu, Yuanyuan Li, Wei Liu, Zhanjun Ding, Hang Ma, Navindra P. Seeram, Yu Mu, Xueshi Huang, and Liya Li

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Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique, Yan Yang, Nan Zheng, Xiaoyue Wang, Ryan Ivone, Weiguang Shan, and Jie Shen

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Sikokianin A from Wikstroemia indica protects PC12 cells against OGD/R-induced injury via inhibiting oxidative stress and activating Nrf2, Huankai Yao, Wenting Zhang, Huiling Wu, Ming Yang, Pengxiang Wei, Hang Ma, Jingyu Duan, Chunping Zhang, and Yan Li

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The Probiotic Bacterium Phaeobacter inhibens Downregulates Virulence Factor Transcription in the Shellfish Pathogen Vibrio coralliilyticus by N-Acyl Homoserine Lactone Production, Wenjing Zhao, Tao Yuan, Christine Piva, Edward J. Spinard, Chrisitan W. Schuttert, David C. Rowley, and David R. Nelson

Submissions from 2018

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Trichophycins B–F, Chlorovinylidene-Containing Polyketides Isolated from a Cyanobacterial Bloom, Matthew Bertin, Josep Sauri, Yizhou Liu, Christopher W. Via, Alexandre F. Roduit, and R. Thomas Williamson

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Identifying and characterizing subpopulations of heavy alcohol drinkers via a sucrose preference test: A sweet road to a better phenotypic characterization?, Sofia Bouhlal, Mehdi Farokhnia, Mary R. Lee, Fatemeh Akhlaghi, and Lorenzo Leggio

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DNA base sequence effects on bulky lesion-induced conformational heterogeneity during DNA replication, Ang Cai, Katie A. Wilson, Satyakam Patnaik, Stacey D. Wetmore, and Bongsup P. Cho

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Augmentation of Vaccine-induced Humoral and Cellular Immunity by a Physical Radiofrequency Adjuvant, Yan Cao, Xiaoyue Zhu, Md Nazir Hossen, Prateek Kakar, Yiwen Zhao, and Xinyuan Chen

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Oral microbiota of periodontal health and disease and their changes after nonsurgical periodontal therapy, Casey Chen, Christopher L. Hemme, Joan Beleno, Zhou Jason Shi, Daliang Ning, Yujia Qin, Qichao Tu, Michael Jorgensen, Zhili He, and Liyou Wu

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A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy, Judianne Davis, Feng Xu, Joshua Hatfield, Hedok Lee, Michael D. Hoos, Dominique Popescu, Elliot Crooks, Regina Kim, Steven O. Smith, John K. Robinson, Helene Benveniste, and William Van Nostrand

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Bile salt export pump: Drug-induced liver injury and assessment approaches, Ruitang Deng

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Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?, Mehdi Farokhnia, Mary R. Lee, Lisa A. Farinelli, Vijay A. Ramchandani, Fatemeh Akhlaghi, and Lorenzo Leggio

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Tacrolimus Concentration in Saliva of Kidney Transplant Recipients: Factors Influencing the Relationship with Whole Blood Concentrations, Mwlod Ghareeb, Reginald Y. Gohh, and Fatemeh Akhlaghi

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MiR-155, a potential serum marker of extramammary Paget's disease, Hao Guo, Rui-Qun Qi, Jie Sheng, Chang Liu, Hang Ma, He-Xiao Wang, Jiu-Hong Li, Xing-Hua Gao, Yin-Sheng Wan, and Hong-Duo Chen

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Beyond the Biomarker: Understanding the Diverse Roles of Human Epididymis Protein 4 in the Pathogenesis of Epithelial Ovarian Cancer, Nicole E. James, Clinton Chichester, and Jennifer R. Ribeiro

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Nonalcoholic Fatty Liver Disease and Diabetes Are Associated with Decreased CYP3A4 Protein Expression and Activity in Human Liver, Rohitash Jamwal, Suzanne M. De La Monte, Ken Ogasawara, Sravani Adusumalli, Benjamin B. Barlock, and Fatemeh Akhlaghi

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Levodopa-Reduced Mucuna pruriens Seed Extract Shows Neuroprotective Effects against Parkinson’s Disease in Murine Microglia and Human Neuroblastoma Cells, Caenorhabditis elegans, and Drosophila melanogaster, Shelby L. Johnson, Hyun Y. Park, Nicholas A. DaSilva, Dhiraj A. Vattem, Hang Ma, and Navindra P. Seeram

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Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells, Bohkyung Kim, Minkyung Bae, Young Ki Park, Hang Ma, Tao Yuan, Navindra P. Seeram, and Ji Young Lee

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Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: Determination using a novel oxytocin assay, M. R. Lee, K. B. Scheidweiler, X. X. Diao, F. Akhlaghi, A. Cummins, M. A. Huestis, L. Leggio, and B. B. Averbeck

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Phenolics from Eugenia jambolana seeds with advanced glycation endproduct formation and alpha-glucosidase inhibitory activities, Feifei Liu, Hang Ma, Guihua Wang, Weixi Liu, Navindra P. Seeram, Yu Mu, Yingjie Xu, Xueshi Huang, and Liya Li

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The combined therapeutic effects of 131iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer, Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Zerong Wang, Jianjun Liu, Xiaoguang Sun, Michel Fulham, Dagan Feng, Zhigang Chen, Shaoli Song, Wei Li, and Gang Huang

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Biotin-Modified Polylactic- co-Glycolic Acid Nanoparticles with Improved Antiproliferative Activity of 15,16-Dihydrotanshinone i in Human Cervical Cancer Cells, Jingjing Luo, Xiaofeng Meng, Jianyu Su, Hang Ma, Wen Wang, Liming Fang, Huade Zheng, Yexia Qin, and Tianfeng Chen

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Fluvirosaones A and B, Two Indolizidine Alkaloids with a Pentacyclic Skeleton from Flueggea virosa, Xiang Kun Luo, Jie Cai, Zhi Yong Yin, Pan Luo, Chan Juan Li, Hang Ma, Navindra P. Seeram, Qiong Gu, and Jun Xu

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Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effect, Hang Ma, Shelby L. Johnson, Weixi Lu, Nicholas A. DaSilva, Susan Meschwitz, Joel A. Dain, and Navindra P. Seeram

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Natural Borneol Enhances Paclitaxel-Induced Apoptosis of ESCC Cells by Inactivation of the PI3K/AKT, Xiaofeng Meng, Xiaomei Dong, Wen Wang, Liu Yang, Xia Zhang, Yanfang Li, Tianfeng Chen, Hang Ma, Da Qi, and Jianyu Su

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Draft Genome Sequence of the Putative Marine Pathogen Aquimarina sp. Strain I32.4, Hilary J. Ranson, Edward Spinard, Andrei Y. Chistoserdov, Marta Gomez-Chiarri, David R. Nelson, and David C. Rowley

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The Effects of Volume Versus Intensity of Long-Term Voluntary Exercise on Physiology and Behavior in C57/Bl6 Mice, Lisa S. Robison, Dominique L. Popescu, Maria E. Anderson, Steven I. Beigelman, Shannon M. Fitzgerald, Antonina E. Kuzmina, David A. Lituma, Sarima Subzwari, Michalis Michaelos, Brenda J. Anderson, William E. Van Nostrand, and John K. Robinson

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Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities, Kenneth Rose, Chunpeng Wan, Amber Thomas, Navindra P. Seeram, and Hang Ma

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Dysregulation of Δ 4 -3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms, Leila Valanejad, Mwlod Ghareeb, Stephanie Shiffka, Christina Nadolny, Yuan Chen, Liangran Guo, Ruchi Verma, Sangmin You, Fatemeh Akhlaghi, and Ruitang Deng

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Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1T, Qihao Wu, Robert W. Deering, Gaiyun Zhang, Bixia Wang, Xin Li, Jiadong Sun, Jianwei Chen, Huawei Zhang, David C. Rowley, and Hong Wang

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Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (: Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice, Jialin Xu, Tingting Liu, Yuanyuan Li, Chunhui Yuan, Hang Ma, Navindra P. Seeram, Feifei Liu, Yu Mu, Xueshi Huang, and Liya Li

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Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways, Jialin Xu, Chunhui Yuan, Guihua Wang, Jiaming Luo, Hang Ma, Li Xu, Yu Mu, Yuanyuan Li, Navindra P. Seeram, Xueshi Huang, and Liya Li

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Nanoparticle Anchoring Targets Immune Agonists to Tumors Enabling Anti-Cancer Immunity Without Systemic Toxicity, Yuan Zhang, Na Li, Heikyung Suh, and Darrel J. Irvine

Submissions from 2017

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Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii, Matthew Bertin, Alexandre Roduit, Jiadong Sun, Gabriella Alves, Christopher Via, Miguel Gonzalez, Paul V. Zimba, and Peter D. R. Moeller

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Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom, Matthew Bertin, Paul G. Wahome, Paul V. Zimba, Haiyin He, and Peter D. R. Moeller

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Sustained epidermal powder drug delivery via skin microchannels, Yan Cao, Prateek Kakar, Md. Nazir Hossen, Mei X. Wu, and Xinyuan Chen

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Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters, Enoch Cobbina and Fatemeh Akhlaghi

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Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks?, Carolina L. Haass-Koffler, Fatemeh Akhlaghi, Robert M. Swift, and Lorenzo Leggio

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Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS, Rohitash Jamwal, Benjamin J. Barlock, Sravani Adusumalli, Ken Ogasawara, Brigitte L. Simons, and Fatemeh Akhlaghi

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Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids, Rohitash Jamwal, Ariel R. Topletz, Bharat Ramratnam, and Fatemeh Akhlaghi

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Thymoquinone Ameliorates Diabetic Phenotype in Diet-Induced Obesity Mice via Activation of SIRT-1-Dependent Pathways, Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela Slitt, and Emma Heart

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New Sesquiterpenoids from Eugenia jambolana Seeds and Their Anti-microbial Activities, Feifei Liu, Chengbin Liu, Wei Liu, Zhanjun Ding, Hang Ma, Navindra P. Seeram, Li Xu, Yu Mu, Xueshi Huang, and Liya Li

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Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds, Feifei Liu, Tao Yuan, Wei Liu, Hang Ma, Navindra P. Seeram, Yuanyuan Li, Li Xu, Yu Mu, Xueshi Huang, and Liya Li

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Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells, Weixi Liu, Zhengxi Wei, Hang Ma, Ang Cai, Yongqiang Liu, Jiadong Sun, Nicholas A. DaSilva, Shelby L. Johnson, Louis J. Kirschenbaum, Bongsup P. Cho, Joel A. Dain, David C. Rowley, Zahir A. Shaikh, and Navindra P. Seeram

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Chemical composition and anti-hyperglycaemic effects of triterpenoid enriched Eugenia jambolana Lam. berry extract, Yuanyuan Li, Jialin Xu, Chunhui Yuan, Hang Ma, Tingting Liu, Feifei Liu, Navindra P. Seeram, Yu Mu, Xueshi Huang, and Liya Li

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Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells, Hang Ma, Jialin Xu, Nicholas A. DaSilva, Ling Wang, Zhengxi Wei, Liangran Guo, Shelby L. Johnson, Wei Lu, Jun Xu, Qiong Gu, and Navindra P. Seeram

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Delivering safer immunotherapies for cancer, Lauren Milling, Yuan Zhang, and Darrell J. Irvine

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Bioactive glucitol-core containing gallotannins and other phytochemicals from silver maple (acer saccharinum) leaves, Abdullatif Bin Muhsinah, Hang Ma, Nicholas A. DaSilva, Tao Yuan, and Navindra P. Seeram

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A Human Gut Commensal Ferments Cranberry Carbohydrates To Produce Formate, Ezgi Özcan, Jiadong Sun, David C. Rowley, and David A. Sela

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Impact of Consuming ‘Toxic’ Monarch Caterpillars on Adult Chinese Mantid Mass Gain and Fecundity, Jamie Rafter, Liahna Gonda-King, Daniel Niesen, Navindra Seeram, Chad Rigsby, and Evan Preisser

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Pretty Picky for a Generalist: Impacts of Toxicity and Nutritional Quality on Mantid Prey Processing, Jamie L. Rafter, Justin F. Vendettuoli, Liahna Gonda-King, Daniel Niesen, Navindra P. Seeram, Chad M. Rigsby, and Evan L. Preisser

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Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease, Prajakta C. Shimpi, Vijay R. More, Maneesha Paranjpe, Ajay C. Donepudi, Jaclyn M. Goodrich, Dana C. Dolinoy, Beverly Rubin, and Angela L. Slitt

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The interactions of single-wall carbon nanohorns with polar epithelium, Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao, Xueqing Wang, and Qiang Zhang