Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (: Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice
Document Type
Article
Date of Original Version
6-1-2018
Abstract
The edible berries of Eugenia jambolana Lam. (known as Jamun) are consumed in various parts of the world. Our previous studies revealed that a triterpenoid-enriched Jamun fruit extract (TJFE) showed beneficial effects on glucose homeostasis in non-diabetic mice. Herein, the anti-diabetic effects of TJFE (100 mg kg-1 by oral gavage for ten days) were evaluated in streptozotocin (STZ)-induced type 1 diabetic mice. TJFE significantly attenuated STZ-induced hyperglycemia and glucose intolerance, suppressed the abnormal elevation of hepatic gluconeogenesis, and improved dyslipidemia in the mice. Histopathology and mechanism-based studies revealed that TJFE preserved the architecture and function of pancreatic islets, attenuated insulin secretion deficiency, enhanced insulin/Akt signaling transduction, reduced lipogenic gene expression, and prevented the abnormal activation of Erk MAPK in the liver tissues of the STZ-induced diabetic mice. The current study adds to previously published data supporting the potential beneficial effects of this edible fruit on diabetes management.
Publication Title, e.g., Journal
Food and Function
Volume
9
Issue
6
Citation/Publisher Attribution
Xu, Jialin, Tingting Liu, Yuanyuan Li, Chunhui Yuan, Hang Ma, Navindra P. Seeram, Feifei Liu, Yu Mu, Xueshi Huang, and Liya Li. "Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (: Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice." Food and Function 9, 6 (2018): 3330-3337. doi: 10.1039/c8fo00095f.