Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1T

Authors

Qihao Wu
Robert W. Deering, University of Rhode IslandFollow
Gaiyun Zhang
Bixia Wang
Xin Li
Jiadong Sun, University of Rhode IslandFollow
Jianwei Chen
Huawei Zhang
David C. Rowley, University of Rhode IslandFollow
Hong Wang

Document Type

Article

Date of Original Version

6-7-2018

Department

Biomedical and Pharmaceutical Sciences

Abstract

Marine actinobacteria continue to be a rich source for the discovery of structurally diverse secondary metabolites. Here we present a new hydroxymate siderophore produced by Amycolatopsis albispora, a recently described species of this less explored actinomycete genus. Strain WP1^T was isolated from sediments collected at −2945 m in the Indian Ocean. The new siderophore, designated albisporachelin, was isolated from iron depleted culture broths and the structure was established by 1D and 2D NMR and MS/MS experiments, and application of a modified Marfey’s method. Albisporachelin is composed of one N-methylated-formylated/hydroxylated l-ornithine (N-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo-N-methylated-hydroxylated l-ornithine (cyclo-N-Me-h-l-Orn).

Citation/Publisher Attribution

Wu, Q.; Deering, R.W.; Zhang, G.; Wang, B.; Li, X.; Sun, J.; Chen, J.; Zhang, H.; Rowley, D.C.; Wang, H. Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1^T. Mar. Drugs 2018, 16, 199.

Available at: https://doi.org/10.3390/md16060199

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.