Publications from the Department of Biomedical and Pharmaceutical Sciences faculty at the University of Rhode Island.

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Submissions from 2013

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Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding, Vijay R. More, Jialin Xu, Prajakta C. Shimpi, Clyde Belgrave, James P. Luyendyk, Masayuki Yamamoto, and Angela L. Slitt

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Synthesis and Evaluation of Cytotoxic Activity of Substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides, Somayeh Motavallizadeh, Asal Asal Fallah-Taftia, Saeedeh Maleki, Amir Nasrolahi Shirazi, Mahboobeh Pordeli, Maliheh Safavi, Sussan Kabudanian Ardestani, Shaaban Asd, Rakesh Tiwari, Donghoon Oh, Abbas Shafiee, Alireza Foroumadi, Keykavous Parang, and Tahmineh Akbarzadeh

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Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients, Ken Ogasawara, Shripad D. Chitnis, Reginald Y. Gohh, Uwe Christians, and Fatemeh Akhlaghi

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Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus, Chirag G. Patel, Ken Ogasawara, and Fatemeh Akhlaghi

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Synthesis and antiproliferative activities of quebecol and its analogs, Kasiviswanadharaju Pericherla, Amir Nasrolahi Shirazi, V. Kameshwara Rao, Rakesh K. Tiwari, Nicholas DaSilva, Kellen T. McCaffrey, Yousef A. Beni, Antonion González-Sarrías, Navindra P. Seeram, Keykavous Parang, and Anil Kumar

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A Simple and Efficient Synthesis of 2,3-Diarylnaphthofurans using Sequential Hydroarylation/Heck Oxyarylation, V. Kameshwara Rao, Gamesh M. Shelke, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Copper(II) triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities, V. Kameshwara Rao, Rakesh Tiwari, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Keykavous Parang, and Anil Kumar

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Structure and thermodynamic insights on acetylaminofluorene-modified deletion DNA duplexes as models for frameshift mutagenesis, Anusha Sandineni, Bin Lin, Alexander D. Mackerell, and Bongsup P. Cho

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Cellular and Organismal Toxicity of the Anti-Cancer Small Molecule, Tolfenamic Acid: A Pre-Clinical Evaluation, Umesh T. Sankpal, Chris M. Lee, Sarah F. Connelly, Omer Kayaleh, Don Eslin, Robert Sutphin, Steven Goodison, Lina Adwan, Nasser H. Zawia, Lenard M. Lichtenberger, and Riyaz Basha

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Plasma Membrane Compartmentalization of D2 Dopamine Receptors, Meenakshi Sharma, Jeremy Celver, J. Christopher Octeau, and Abraham Kovoor

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Peptide-Amphiphile Containing Arginine and Fatty Acyl Chains as Molecular Transporters, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Kumar Tiwari, Brian Sullivan, Anju Gupta, Geoffrey D. Bothun, and Keykavous Parang

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Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Alex Brown, Dindyal Mandal, Gongqin Sun, and Keykavous Parang

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Efficient Delivery of Cell Impermeable Phosphopeptides by a Cyclic Peptide Amphiphile Containing Tryptophan and Arginine, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Donghoon Oh, Antara Banarjee, Arpita Yadav, and Keykavous Parang

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Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Donghoon Oh, Brian Sullivan, Kellen McCaffrey, Dindyal Mandal, and Keykavous Parang

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Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor, Xiulong Song, Yuan Chen, Leila Valanejad, Rajani Kaimal, Bingfang Yan, Matthew Stoner, and Ruitang Deng

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Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice, Gehad M. Subaiea, Lina I. Adwan, Aseef H. Ahmed, Karen E. Stevens, and Nasser H. Zawia

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Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines, Narva Suresh, Hunsur Nagendra Nagesh, Kondapalli V. G. C. Sekhar, Anil Kumar, Amir N. Shirazi, and Keykavous Parang

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Insights into the Conformation of Aminofluorene-Deoxyguanine Adduct in a DNA Polymerase Active Site, Vaidyanathan G. Vaidyanathan, Fengting Liang, William A. Beard, David D. Shock, Samuel H. Wilson, and Bongsup P. Cho

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Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs, Da Xiao, Deshi Shi, Dongfang Yang, Benjamin Barthel, Tad H. Koch, and Bingfang Yan

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Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue, Jialin Xu, Ajay C. Donepudi, Jamie E. Moscovitz, and Angela Slitt

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pHLIP peptide targets nanogold particles to tumors, Lan Yao, Jennifer Daniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana Reshetnyak, and Oleg A. Andreev

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New phenolics from the flowers of punica granatum and their in vitro α-glucosidase inhibitory activities, Tao Yuan, Chunpeng Wan, Hang Ma, and Navindra P. Seeram

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ABCC3 as a marker for multidrug resistance in non-small cell lung cancer, Yanbin Zhao, Hailing Lu, An Yan, Yanmei Yang, Qingwei Meng, Lichun Sun, Hui Pang, Chunhong Li, Xiaoqun Dong, and Li Cai

Submissions from 2012

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Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors, Hitesh K. Agarwal, Karen W. Buckheit, Robert W. Buckheit Jr., and Keykavous Parang

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The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus, Fatemeh Akhlaghi, Miroslav Dostalek, Pål Falck, Anisha E. Mendonza, Rune Amundsen, Reginald Y. Gohh, and Anders Åsberg

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Integration of genome-wide expression and methylation data: Relevance to aging and Alzheimer's disease, Hany Alashwal, Remi Dosunmu, and Nasser H. Zawia

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Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides, Floyd A. Beckford, Jeffrey Thessing, Alyssa Stott, Alvin A. Holder, Oleg G. Poluetov, Liya Li, and Navindra P. Seeram

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Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2, Yi-Tzai Chen, Deshi Shi, Dongfang Yang, and Bingfang Yan

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N-Myristoylglutamic acid derivative of 3′-fluoro-3′-deoxythymidine as an organogel, Bhupender S. Chhikara, Rakesh Tiwari, and Keykavous Parang

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Developmental exposure to lead (Pb) alters the expression of the human tau gene and its products in a transgenic animal model, M. Dash, A. Eid, G. Subaiea, J. Chang, R. Deeb, A. Masoud, William E. Renehan, A. Adem, and Nasser H. Zawia

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A review of the hypoglycemic effects of five commonly used herbal food supplements, Ruitang Deng

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Pharmacy Research at URI: Bile Acids and Bile Salt Export Pump: Physiology and Pathology, Ruitang Deng

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Effect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs, Miroslav Dostalek, Fatemeh Akhlaghi, and Martina Puzanovova

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Diabetes mellitus reduces the clearance of atorvastatin lactone: Results of a population pharmacokinetic analysis in renal transplant recipients and in vitro studies using human liver microsomes, Miroslav Dostalek, Wai Johnn Sam, Komal R. Paryani, Joyce S. MacWan, Reginald Y. Gohh, and Fatemeh Akhlaghi

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Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging, Remi Dosunmu, Hany Alashwal, and Nasser H. Zawia

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In vitro Transdermal Permeation of Fenoterol Hydrobromide, Ahmed H. Elshafeey, Yassin E. Hamza, Soad Y. Amin, and Hossein Zia

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Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A, Avelina Espinosa, Aaron M. Socha, Erica Ryke, and David C. Rowley

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Going Deep for Drug Discovery: An Ocean to Bedside Approach to Explore Sub-Seafloor Microbes for the Next Generation of Antibiotics, Stephanie Forschner-Dancause, L. LaPlante, David C. Smith, and David C. Rowley

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Strong Association Between Two Polymorphisms on 15q25.1 and Lung Cancer Risk: A Meta-Analysis, Mingliang Gu, Xiaoqun Dong, Xuezhi Zhang, Xumin Wang, Yue Qi, Jun Yu, and Wenquan Niu

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Combination of TRAIL and actinomycin D liposomes enhances antitumor effect in non-small cell lung cancer, Liangran Guo, Li Fan, Jinfeng Ren, Zhiqing Pang, Yulong Ren, Jingwei Li, Ziyi Wen, Yong Qian, Lin Zhang, Hang Ma, and Xinguo Jiang

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Synergistic Association of PTGS2 and CYP2E1 Genetic Polymorphisms with Lung Cancer Risk in Northeastern Chinese, Shujie Guo, Xiaobo Li, Min Gao, Hong Kong, Yuqiong Li, Mingliang Gu, Xiaoqun Dong, and Wenquan Niu

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Unusual Sequence Effects on Nucleotide Excision Repair of Arylamine Lesions: DNA Bending/Distortion as a Primary Recognition Factor, Vipin Jain, Benjamin Hilton, Bin Lin, Satyakam Patnaik, Fengting Liang, Eva Darian, Yue Zou, Alexander D. MacKerell Jr., and Bongsup P. Cho

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Conformational and Thermodynamic Properties Modulate the Nucleotide Excision Repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI Sequence, Vipin Jain, Benjamin Hilton, Satyakam Patnaik, Yue Zou, M. Paul Chiarelli, and Bongsup P. Cho

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Association of the 5-HTT Gene-Linked Promoter Region (5-HTTLPR) Polymorphism with Psychiatric Disorders: Review of Psychopathology and Pharmacotherapy, George A. Kenna, Nick Roder-Hanna, Lorenzo Leggio, William H. Zywiak, James Clifford, Steven Edwards, John A. Kenna, Jessica Shoaff, and Robert M. Swift

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Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease, Lisa Longato, Kelsey Ripp, Mashiko Setshedi, Miroslav Dostalek, Fatemeh Akhlaghi, Mark Branda, Jack R. Wands, and Suzanne M. de la Monte

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Nanoparticles for Cancer Treatment, Wei Lu

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A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS), Joyce S. MacWan, Ileana A. Ionita, and Fatemeh Akhlaghi

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New galloyl derivative from winged sumac (Rhus copallinum) fruit, Hang Ma, Tao Yuan, Antonio Gonzaĺez-Sarrías, Liya Li, Maxwell E. Edmonds, and Navindra P. Seeram

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DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes, Zhao Mao, Xiaofei Luan, Gang Cao, Wei Liu, Jing Xiong, Gang Hu, Ruini Chen, Rui Ning, Wei Shang, Jian Yang, and Bingfang Yan

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Severe Diabetes and Leptin Resistance Cause Differential Hepatic and Renal Transporter Expression in Mice, Vijay More, Xia Wen, Paul E. Thomas, Lauren M. Aleksunes, and Angela L. Slitt

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Quantitative Analysis of Some Important Metals and Metalloids in Tobacco Products by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Syed Ghulam Musharraf, Muhammad Shoaib, Amna Jabbar Siddiqui, Muhammad Najam-ul-Haq, and Aftab Ahmed

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4-Aryl-4H-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation of Src Kinase Inhibitory and Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Deendayal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, and Tahmineh Akbarzadeh

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One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities, V. Kameshwara Rao, Bhupender S. Chhikara, Rakesh Tiwari, Amir Nasrolahi Shirazi, Keykavous Parang, and Anil Kumar

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Pharmacy Research at URI: Mining Red Maple (Acer rubrum) Trees for Novel Therapeutics to Manage Diabetes, Navindra P. Seeram, Jialin Xu, Liya Li, and Angela Slitt

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Hepatic immunosuppressive effects of systemically administered novel dextran–methylprednisolone prodrugs with peptide linkers in rats, Imam H. Shaik, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Intranasal ketamine for procedural sedation in pediatric laceration repair: A preliminary report, Daniel S. Tsze, Dale W. Steele, Jason T. MacHan, Fatemeh Akhlaghi, and James G. Linakis

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Sequence effects on translesion synthesis of an aminofluorene-DNA adduct: Conformational, thermodynamic, and primer extension kinetic studies, V. G. Vaidyanathan and Bongsup P. Cho

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Binary and ternary binding affinities between exonuclease-deficient Klenow Fragment (Kf-exo-) and various arylamine DNA lesions characterized by surface plasmon resonance, V. G. Vaidyanathan, Lifang Xu, and Bongsup P. Cho

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Community annotation and bioinformatics workforce development in concert—Little Skate Genome Annotation Workshops and Jamborees, Qinghua Wang, Cecilia N. Arighi, Benjamin L. King, Shawn W. Polson, James Vincent, Chumching Chen, Hongzhan Huang, Brewster F. Kingham, Shallee T. Page, Marc Farnum Rendino, William Kelley Thomas, Daniel W. Udwary, and Cathy H. Wu

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Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation, Da Xiao, Yi-Tzai Chen, Dongfang Yang, and Bingfang Yan

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Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice, Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, and Angela L. Slitt

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Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump, Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, and Bingfang Yan

Submissions from 2011

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Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine, Yousef Ahmadibeni, Rakesh Tiwari, Chelsie Swepson, Jui Pandhare, Chandravanu Dash, Gustavo F. Doncel, and Keykavous Parang

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Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents, Floyd A. Beckford, Jeffrey Thessing, Michael Shaloski Jr., P. Canisius Mbarushimana, Alyssa Brock, Jacob Didion, Jason Woods, Antonio Gonzalez-Sarrías, and Navindra P. Seeram

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Half-sandwich ruthenium–arene complexes with thiosemicarbazones: Synthesis and biological evaluation of [(η6-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes, Floyd Beckford, Deidra Dourth, Michael Shaloski Jr., Jacob Didion, Jeffrey Thessing, Jason Woods, Vernon Crowell, Nikolay Gerasimchuk, Antonio Gonzalez-Sarrías, and Navindra P. Seeram

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Mycophenolic acid in kidney transplant patients with diabetes mellitus: Does the formulation matter?, Paul Bolin, Reginald Gohh, Raja Kandaswamy, Faud S. Shihab, Anne Wiland, Fatemeh Akhlaghi, and Keith Melancon

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Multicomponent folate-targeted magnetoliposomes: design, characterization, and cellular uptake, Geoffrey D. Bothun, Alline Lelis, Yanjing Chen, Kyle Scully, Linnea E. Anderson, and Matthew A. Stoner

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Constitutive activation of nuclear factor‐E2‐related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte‐specific deletion of Kelch‐like ECH‐associated protein 1, Qiuqiong Cheng, Keiko Taguchi, Lauren M. Aleksunes, José E. Manautou, Nathan J. Cherrington, Masayuki Yamamoto, and Angela L. Slitt

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Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates, Chandravanu Dash, Yousef Ahmadibeni, Michael J. Hanley, Jui Pandhare, Mathias Gotte, Stuart F.J. Le Grice, and Keykavous Parang

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Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite, Miroslav Dostalek, Michael H. Court, Suwagmani Hazarika, and Fatemeh Akhlaghi

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Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus, Miroslav Dostalek, Michael H. Court, Bingfang Yan, and Fatemeh Akhlaghi

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Enhanced Bioavailability of Fenoterol Transdermal Systems in Rabbits, A. H. Elshafeey, Y. E. Hamza, S. Y. Amin, Fatemeh Akhlaghi, and H. Zia

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Substituted Coumarin Derivatives: Synthesis and Evaluation of Antiproliferative and Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, and Sunil K. Sharma

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Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities, Anil Kumar, Israr Ahmad, Bhupender S. Chhikara, Rakesh Tiwari, Deendayal Mandal, and Keykavous Parang

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Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity, Dalip Kumar, V. Buchi Reddy, Anil Kumar, Deendayal Mandal, Rakesh Tiwari, and Keykavous Parang

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Conformational and thermodynamic impact of bulky aminofluorene adduction on simulated translesion DNA synthesis, Fengting Liang and Bongsup P. Cho

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Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS), Joyce S. MacWan, Ileana A. Ionita, Miroslav Dostalek, and Fatemeh Akhlaghi

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Harnessing the power of genomics and immunoinformatics to produce improved vaccines, Leonard Moise, Leslie Cousens, Joanna Fueyo, and Anne S. De Groot

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Molecular Characterization of Novel Sulfotransferases from the Tick, Ixodes scapularis, Sivakamasundari Pichu, Emine Bihter Yalcin, José MC Ribeiro, Roberta S. King, and Thomas N. Mather

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Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: An SAR study, Shashikanth Ponnala, Sandeep Chaudhary, Antonio González-Sarrias, Navindra P. Seeram, and Wayne W. Harding

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3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities, K. Kameshwara Rao, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Regulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells, Meenakshi Sharma, Jeremy Celver, and Abraham Kovoor

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Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses, Daniel W. Udwary, Erin A. Gontang, Adam C. Jones, Carla S. Jones, Andrew W. Schultz, Jaclyn M. Winter, Jane Y. Yang, Nicholas Beauchemin, Todd L. Capson, Benjamin R. Clark, Eduardo Esquenazi, Alessandra S. Eustáquio, Kelle Freel, Lena Gerwick, William H. Gerwick, David Gonzalez, Wei-Ting Liu, Karla L. Malloy, Katherine N. Maloney, Markus Nett, Joshwana K. Nunnery, Kevin Penn, Alejandra Prieto-Davo, Thomas L. Simmons, Sara Weitz, Michael C. Wilson, Louis S. Tisa, Pieter C. Dorrestein, and Bradley S. Moore

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Association between Regulator of G Protein Signaling 9–2 and Body Weight, Jeffrey L. Waugh, Celver, Meenakshi Sharma, Robert L. Dufresne, Dimitra Terzi, S. Craig Risch, William G. Fairbrother, Rachael L. Neve, John P. Kane, Mary J. Malloy, Clive R. Pullinger, Harvest F. Gu, Christos Tsatsanis, Steven P. Hamilton, Stephen J. Gold, Venetia Zachariou, and Abraham Kovoor

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Monoamine Neurotransmitters as Substrates for Novel Tick Sulfotransferases, Homology Modeling, Molecular Docking, and Enzyme Kinetics, Emine Bihter Yalcin, Hubert Strangl, Sivakamasundari Pichu, Thomas N. Mather, and Roberta S. King

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Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor, Dongfang Yang, Jian Yang, Deshi Shi, Ruitang Deng, and Bingfang Yan

Submissions from 2010

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Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, and Keykavous Parang

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Synthesis of nucleoside 5′-O-α,β-methylene-β-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase, Yousef Ahmadibeni, Chandravanu Dash, Michael J. Hanley, Stuart F.J. Le Grice, Hitesh K. Agarwal, and Keykavous Parang

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Solid-phase synthesis of 5′-O-β,γ-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase, Yousef Ahmadibeni, Chandravanu Dash, Stuart F.J. Le Grice, and Keykavous Parang

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The level of ATP production in mitogen-stimulated CD4+ lymphocytes is independent of the time of ingestion of immunosuppressive agents, Fatemeh Akhlaghi and Reginald Y. Gohh

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Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR), Linnea E. Anderson, Ann M. Dring, Laura D. Hamel, and Matthew A. Stoner

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Structure-Function Characteristics of Aromatic Amine-DNA Adducts, Bongsup Cho

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Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae spirulina, Ruitang Deng and Te Jin Chow

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Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1′-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry, Miroslav Dostalek, Joyce S. Macwan, Shripad D. Chitnis, Ileana A. Ionita, and Fatemeh Akhlaghi

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Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands, Ann M. Dring, Linnea E. Anderson, Saima Qamar, and Matthew A. Stoner

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Comparison of plasma clearance of iodixanol during versus after angiography, Susie Hu, Fatemeh Akhlaghi, Shripad Chitnis, Ritche Chiu, Subil Go, Preeti Rout, Michael Steffes, J. Dawn Abbott, Lance Dworkin, and Andrew Bostom

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Quantification of unbound prednisolone, prednisone, cortisol and cortisone in human plasma by ultrafiltration and direct injection into liquid chromatrography tandem mass spectrometry, I. A. Ionita and F. Akhlaghi

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Enthalpy - entropy contribution to carcinogen-induced DNA conformational heterogeneity, Fengting Liang and Bongsup P. Cho

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Phenolics from Cornus amomum Mill. fruit, Hang Ma, Liya Li, and Navindra P. Seeram

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Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11·Gβ5 Complex and Accelerates Inactivation of the mGluR6-G0 Signaling, Ikuro Masuho, Jeremy Celver, Abraham Kovoor, and Kirill A. Martemyanov