Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom

Authors

Matthew Bertin, University of Rhode IslandFollow
Paul G. Wahome
Paul V. Zimba
Haiyin He
Peter D. R. Moeller

Document Type

Article

Date of Original Version

1-5-2017

Department

Biomedical and Pharmaceutical Sciences

Abstract

In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC₅₀: 6.5 μM) and HCT-116 cells (EC₅₀: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds.

Citation/Publisher Attribution

Bertin, M.J.; Wahome, P.G.; Zimba, P.V.; He, H.; Moeller, P.D.R. Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom. Mar. Drugs 2017, 15, 10. https://doi.org/10.3390/md15010010

Available at: https://doi.org/10.3390/md15010010

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.