Document Type
Article
Date of Original Version
2020
Department
Biomedical and Pharmaceutical Sciences
Abstract
The trichophycin family of compounds are chlorinated polyketides first discovered from environmental collections of a bloom-forming Trichodesmium sp. cyanobacterium. In an effort to fully capture the chemical space of this group of metabolites, the utilization of MS/MS-based molecular networking of a Trichodesmium thiebautii extract revealed a metabolome replete with halogenated compounds. Subsequent MS-guided isolation resulted in the characterization of isotrichophycin C and trichophycins G–I (1–4). These new metabolites had intriguing structural variations from those trichophycins previously characterized, which allowed for a comparative study to examine structural features that are associated with toxicity to murine neuroblastoma cells. Additionally, we propose the absolute configuration of the previously characterized trichophycin A (5). Overall, the metabolome of the Trichodesmium bloom is hallmarked by an unprecedented amount of chlorinated molecules, many of which remain to be structurally characterized.
Citation/Publisher Attribution
McManus, K. M., Kirk, R. D., Via, C. W., Lotti, J. S., Roduit, A. F., Teta, R.,...Bertin, M. J. (2020). Isolation of Isotrichophycin C and Trichophycins G–I from a Collection of Trichodesmium thiebautii. J. Nat. Prod., 83(9), 2664-2671. doi: 10.1021/acs.jnatprod.0c00550
Available at: https://doi.org/10.1021/acs.jnatprod.0c00550
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