Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds

Authors

Feifei Liu, Northeastern University
Tao Yuan, Xinjiang Technical Institute of Physics and Chemistry
Wei Liu, Northeastern University
Hang Ma, University of Rhode Island
Navindra P. Seeram, University of Rhode Island
Yuanyuan Li, Northeastern University
Li Xu, Northeastern University
Yu Mu, Northeastern University
Xueshi Huang, Northeastern University
Liya Li, Northeastern University

Document Type

Article

Date of Original Version

2-24-2017

Abstract

Fifteen new phloroglucinol derivatives, jamunones A-O (1-8 and 10-16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1-9, 11, 12, and 14-16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 μM.

Publication Title, e.g., Journal

Journal of Natural Products

Volume

80

Issue

2

Citation/Publisher Attribution

Liu, Feifei, Tao Yuan, Wei Liu, Hang Ma, Navindra P. Seeram, Yuanyuan Li, Li Xu, Yu Mu, Xueshi Huang, and Liya Li. "Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds." Journal of Natural Products 80, 2 (2017): 544-550. doi: 10.1021/acs.jnatprod.6b01073.