Publications from the Department of Biomedical and Pharmaceutical Sciences faculty at the University of Rhode Island.

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Submissions from 2011

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Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: An SAR study, Shashikanth Ponnala, Sandeep Chaudhary, Antonio González-Sarrias, Navindra P. Seeram, and Wayne W. Harding

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3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities, K. Kameshwara Rao, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Regulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells, Meenakshi Sharma, Jeremy Celver, and Abraham Kovoor

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Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses, Daniel W. Udwary, Erin A. Gontang, Adam C. Jones, Carla S. Jones, Andrew W. Schultz, Jaclyn M. Winter, Jane Y. Yang, Nicholas Beauchemin, Todd L. Capson, Benjamin R. Clark, Eduardo Esquenazi, Alessandra S. Eustáquio, Kelle Freel, Lena Gerwick, William H. Gerwick, David Gonzalez, Wei-Ting Liu, Karla L. Malloy, Katherine N. Maloney, Markus Nett, Joshwana K. Nunnery, Kevin Penn, Alejandra Prieto-Davo, Thomas L. Simmons, Sara Weitz, Michael C. Wilson, Louis S. Tisa, Pieter C. Dorrestein, and Bradley S. Moore

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Association between Regulator of G Protein Signaling 9–2 and Body Weight, Jeffrey L. Waugh, Jeremy Celver, Meenakshi Sharma, Robert L. Dufresne, Dimitra Terzi, S. Craig Risch, William G. Fairbrother, Rachael L. Neve, John P. Kane, Mary J. Malloy, Clive R. Pullinger, Harvest F. Gu, Christos Tsatsanis, Steven P. Hamilton, Stephen J. Gold, Venetia Zachariou, and Abraham Kovoor

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Monoamine Neurotransmitters as Substrates for Novel Tick Sulfotransferases, Homology Modeling, Molecular Docking, and Enzyme Kinetics, Emine Bihter Yalcin, Hubert Strangl, Sivakamasundari Pichu, Thomas N. Mather, and Roberta S. King

Submissions from 2010

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Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, and Keykavous Parang

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Synthesis of nucleoside 5′-O-α,β-methylene-β-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase, Yousef Ahmadibeni, Chandravanu Dash, Michael J. Hanley, Stuart F.J. Le Grice, Hitesh K. Agarwal, and Keykavous Parang

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Solid-phase synthesis of 5′-O-β,γ-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase, Yousef Ahmadibeni, Chandravanu Dash, Stuart F.J. Le Grice, and Keykavous Parang

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Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR), Linnea E. Anderson, Ann M. Dring, Laura D. Hamel, and Matthew A. Stoner

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Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands, Ann M. Dring, Linnea E. Anderson, Saima Qamar, and Matthew A. Stoner

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Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11·Gβ5 Complex and Accelerates Inactivation of the mGluR6-G0 Signaling, Ikuro Masuho, Jeremy Celver, Abraham Kovoor, and Kirill A. Martemyanov

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Plasma Pharmacokinetics and Tissue Disposition of Novel Dextran–Methylprednisolone Conjugates With Peptide Linkers in Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23, Deshi Shi, Dongfang Yang, and Bingfang Yan

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Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes, Jian Yang, Chunshu Hao, Dongfang Yang, Deshi Shi, Xiulong Song, Xiaofei Luan, Gang Hu, and Bingfang Yan

Submissions from 2009

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Synthesis of Nucleoside Mono-, Di-, and Triphosphoramidates from Solid-Phase cycloSaligenyl Phosphitylating Reagents, Yousef Ahmadibeni, Rakesh K. Tiwari, Gongqin Sun, and Keykavous Parang

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Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η6-p-cymene)Ru(NS)Cl]+ (NS = 9-anthraldehyde thiosemicarbazones), Floyd A. Beckford, Gabriel Leblanc, Jeffrey Thessing, Michael Shaloski Jr., Brian J. Frost, Liya Li, and Navindra P. Seeram

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Influence of Flanking Sequence Context on the Conformational Flexibility of Aminofluorene-Modified dG Adduct in dA Mismatch DNA Duplexes, Nidhi Jain, Srinivasarao Meneni, Vipin Jain, and Bongsup P. Cho

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Eugenia jambolana Lam. Berry Extract Inhibits Growth and Induces Apoptosis of Human Breast Cancer but Not Non-Tumorigenic Breast Cells, Liya Li, Lynn S. Adams, Shiuan Chen, Caroline Killian, Aftab Ahmed, and Navindra P. Seeram

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Secondary Metabolites Produced by the Marine Bacterium Halobacillus salinus That Inhibit Quorum Sensing-Controlled Phenotypes in Gram-Negative Bacteria, Margaret E. Teasdale, Jianyuan Liu, Joselynn Wallace, Fatemeh Akhlaghi, and David C. Rowley

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Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin, Dongfang Yang, Robin e. Pearce, Xiliang Wang, Roger Gaedigk, Yu-Jui Yvonne Wan, and Bingfang Yan

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Pyrethroid insecticides: Isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor, Dongfeng Yang, Xiliang Wang, Yi-tzai Chen, Ruitang Deng, and Bingfang Yan

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Synthesis and evaluation of phosphopeptides containing iminodiacetate groups as binding ligands of the Src SH2 domain, Guofeng Ye, Aaron D. Schuler, Yousef Ahmadibeni, Joel R. Morgan, Absar Faruqui, Kezhen Huang, Gongqin Sun, John A. Zebala, and Keykavous Parang

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Epigenetics, oxidative stress, and Alzheimer disease, Nasser H. Zawia, Debomoy K. Lahiri, and Fernando Cardozo-Pelaez

Submissions from 2008

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An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients, Daniel J. Abrams, Lijun Zheng, Kevin S. Choo, Jun J. Yang, Wei Wei, Thomas J. Anchordoquy, Nasser H. Zawia, and Karen E. Stevens

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Natural Products Chemistry and Taxonomy of the Marine Cyanobacterium Blennothrix cantharidosmum, Benjamin R. Clark, Niclas Engene, Margaret E. Teasdale, David C. Rowley, Teatulohi Matainaho, Frederick A. Valeriote, and William H. Gerwick

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Fluorescence Probing of Aminofluorene-Induced Conformational Heterogeneity in DNA Duplexes, Nidhi Jain, Yana K. Reshetnyak, Lan Gao, M. Paul Chiarelli, and Bongsup P. Cho

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In Vitro and In Vivo Evidence for Lack of Endovascular Remodeling by Third Trimester Trophoblasts, S. Kalkunte, Z. Lai, N. Tewari, Clinton O. Chichester III, R. Romero, J. Padbury, and S. Sharma

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Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium, Zhiwei Liu, Xinyuan Yu, and Zahir A. Shaikh

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DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence, Yingjuan Qian, Jin Zhang, Bingfang Yan, and Xinbin Chen

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Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: Evidence for an involvement of the glucocorticoid receptor, Deshi Shi, Jian Yang, Dongfang Yang, and Bingfang Yan

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Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression, Xiulong Song, Rajani Kaimal, Bingfang Yan, and Ruitang Deng

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Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD, Jinfang Wu, Md. Riyaz Basha, Brian Brock, David P. Cox, Fernando Cardozo-Pelaez, Christopher A. McPherson, Jean Harry, Deborah C. Rise, Brian Maloney, Demaio Chen, Debomoy K. Lahiri, and Nasser H. Zawia

Submissions from 2007

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Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event, Rasha Bhandari, Adolfo Saiardi, Yousef Ahmadibeni, Adele M. Snowman, Adam C. Resnick, Troels Z. Kristiansen, Henrik Molina, Akhilesh Pandey, J. Kent Werner Jr., Krishna R. Juluri, Yong Xu, Glenn D. Prestwich, Keykavous Parang, and Solomon H. Snyder

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Synthesis and antifungal properties of α-methoxy and α-hydroxyl substituted 4-thiatetradecanoic acids, Néstor M. Carballeira, Rosann O'Neill, and Keykavous Parang

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Examination of the Long-range Effects of Aminofluorene-induced Conformational Heterogeneity and Its Relevance to the Mechanism of Translesional DNA Synthesis, Srinivasarao Meneni, Fengting Liang, and Bongsup P. Cho

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Synthesis and in Vitro Characterization of Novel Dextran–Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Synthesis and Evaluation of Tripodal Peptide Analogues for Cellular Delivery of Phosphopeptides, Guofeng Ye, Nguyen-Hai Nam, Anil Kumar, Ali Saleh, Dinesh B. Shenoy, Mansoor M. Amiji, Xiaofeng Lin, Gongqin Sun, and Keykavous Parang

Submissions from 2006

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2,6‐hexadecadiynoic acid and 2,6‐nonadecadiynoic acid: Novel synthesized acetylenic fatty acids as potent antifungal agents, Néstor M. Carballeira, David Sanabria, Clarisa Cruz, Keykavous Parang, Baojie Wan, and Scott Franzblau

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Cooperation between MEF2 and PPARγ in Human Intestinal β,β-Carotene 15,15'-Monooxygenase Gene Expression, Xiaoming Gong, Shu-Whei Tsai, Bingfang Yan, and Lewis P. Rubin

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Synthesis of Polymer-Bound 4-Acetoxy-3-phenylbenzaldehyde Derivatives:  Applications in Solid-Phase Organic Synthesis, Anil Kumar, Guofeng Ye, Yousef Ahmadibeni, and Keykavous Parang

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Docking-based Substrate Recognition by the Catalytic Domain of a Protein Tyrosine Kinase, C-terminal Src Kinase (Csk), Sungsoo Lee, Marina K. Ayrapetov, David J. Kemble, Keykavous Parang, and Gongqin Sun

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Sequence effects of aminofluorene-modified DNA duplexes: thermodynamic and circular dichroism properties, Srinivasa Rao Meneni, Rhijuta D'Mello, Gregory Norigian, Gregory Baker, Lin Gao, M. Paul Chiarelli, and Bongsup P. Cho

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Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells, Changlin Zhou, Lihua Qiu, Yun Sun, Sarah Healey, Harold Wanebo, Nicola Kouttab, Wen Di, Bingfang Yan, and Yinsheng Wan

Submissions from 2005

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Plasma Clearance of Lovastatin Versus Chinese Red Yeast Rice in Healthy Volunteers, Zhaoping Li, Navindra P. Seeram, Rupo Lee, Gail Thames, Chayo Minutti, He-Jing Wang, and David Heber

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Antagonistic Interactions among Marine Bacteria Impede the Proliferation of Vibrio cholerae, Richard A. Long, David C. Rowley, Eric Zamora, Jiayuan Liu, Douglas H. Bartlett, and Farooq Azam

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The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain, M. Riyaz Basha, Wei Wei, Saleh A. Bakheet, Nathalie Benitez, Hasan K. Siddiqi, Yuan-Wen Ge, Debomoy K. Lahiri, and Nasser H. Zawia

Submissions from 2004

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Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease, Thomas Force, Keisuke Kuida, Mark Namchuk, Keykavous Parang, and John M. Kyriakis

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Synthesis and spectroscopic characterization of some chromanochalcones and their dihydro derivatives, M. Srinivasa Rao, J. Kotesh, R. Narukulla, and H. Duddeck

Submissions from 2003

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DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter, Yuxin Li, Mingxing Xie, Xiulong Song, Sarah Gragen, Karuna Sachdeva, Yinsheng Wan, and Bingfang Yan

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Relationship between reproductive success and male plasma vitellogenin concentrations in cunner, Tautogolabrus adspersus, Lesley J. Mills, Ruth E. Gutjahr-Gobell, Doranne Borsay Horowitz, Nancy D. Denslow, Marjorie C. Chow, and Gerald E. Zaroogian

Submissions from 2000

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A Population Pharmacokinetic Analysis of Nelfinavir Mesylate in Human Immunodeficiency Virus-Infected Patients Enrolled in a Phase III Clinical Trial, Kimberly A. Jackson, Sara E. Rosenbaum, Bradley M. Kerr, Yazdi K. Pithavala, Geoffrey Yuen, and Michael N. Dudley

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Demographics and the Cost of Pharmaceuticals in a Private Third-Party Prescription Program, Soyal R. Momin, E. Paul Larrat, David P. Lipson, Rita M. Marcoux, and Lisa L. Harlow

Submissions from 1998

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In Vitro Anti-Hepatitis B Virus Activities of 5’-O-Myristoyl Analogue Derivatives of 3’-Fluoro-2’,3’-dideoxythymidine (FLT) and 3’-Azido-2’,3’- dideoxythymidine (AZT), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus, Jyy-Shiang Huang, and David L. Tyrrell

Submissions from 1995

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Metal Transport in Cells: Cadmium Uptake by Rat Hepatocytes and Renal Cortical Epithelial Cells, Zahir A. Shaikh, Mark E. Blazka, and Tetsuya Endo

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Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine., Victor Skita, David W. Chester, Carey J. Oliver, Joe G. Turcotte, and Robert H. Notter

Submissions from 1994

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Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D, Modechai Liscovitch, Vered Chalifa, Paolo Pertile, Ching-Shih Chen, and Lewis C. Cantley

Submissions from 1993

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Purification and Characterization of Novel “2-Arylpropionyl-CoA Epimerases” from Rat Liver Cytosol and Mitochondria, Woan-Ru Shieh and Ching-Shih Chen

Submissions from 1982

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Recent Progress in Marine Toxin Rsearch, Yuzuru Shimizu