Document Type
Article
Date of Original Version
2013
Department
Biomedical and Pharmaceutical Sciences
Abstract
Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 μM after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC50 values for compounds 7c, 7d, and 7f were 85.1 μM, 78.7 μM, and 80.6 μM against MCF-7 cell line, respectively, showing slightly higher antiproliferative activtiy than the synthesized and isolated quebecol with an IC50 value of 104.2 μM against MCF-7.
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Citation/Publisher Attribution
Pericherla, K., Shirazi, A. N., Rao, V. K., Tiwari, R. K., DaSilva, N., McCaffrey, K. T., Beni, Y. A.,...Kumar, A. (2013). Synthesis and antiproliferative activities of quebecol and its analogs. Bioorganic & Medicinal Chemistry Letters, 23(19), 5329-5331. doi: 10.1016/j.bmcl.2013.07.058
Available at: https://doi.org/10.1016/j.bmcl.2013.07.058
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