Title
DNA-binding studies of the natural β-carboline eudistomin U
Document Type
Article
Date of Original Version
1-1-2016
Abstract
Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV–Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
Publication Title, e.g., Journal
Bioorganic and Medicinal Chemistry Letters
Volume
26
Issue
19
Citation/Publisher Attribution
Giulietti, Jennifer M., Patrick M. Tate, Ang Cai, Bongsup Cho, and Seann P. Mulcahy. "DNA-binding studies of the natural β-carboline eudistomin U." Bioorganic and Medicinal Chemistry Letters 26, 19 (2016): 4705-4708. doi: 10.1016/j.bmcl.2016.08.047.