DNA-binding studies of the natural β-carboline eudistomin U

Authors

Jennifer M. Giulietti, Providence College
Patrick M. Tate, Providence College
Ang Cai, University of Rhode Island
Bongsup Cho, University of Rhode Island
Seann P. Mulcahy, Providence College

Document Type

Article

Date of Original Version

1-1-2016

Abstract

Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV–Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.

Publication Title, e.g., Journal

Bioorganic and Medicinal Chemistry Letters

Volume

26

Issue

19

Citation/Publisher Attribution

Giulietti, Jennifer M., Patrick M. Tate, Ang Cai, Bongsup Cho, and Seann P. Mulcahy. "DNA-binding studies of the natural β-carboline eudistomin U." Bioorganic and Medicinal Chemistry Letters 26, 19 (2016): 4705-4708. doi: 10.1016/j.bmcl.2016.08.047.