Document Type
Article
Date of Original Version
2014
Department
Biomedical and Pharmaceutical Sciences
Abstract
Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pyloriinfected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection.
Citation/Publisher Attribution
Liu, J., Liu, H., Zhang, T., Ren, X., Nadolny, C., Dong, X., Huang, L.,...Jia, Y. (2014). Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer. Scientific Reports, 4:4143. doi: 10.1038/srep04143
Available at: https://doi.org/10.1038/srep04143
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Supplementary Information