Intranasal ketamine for procedural sedation in pediatric laceration repair: A preliminary report
Document Type
Article
Date of Original Version
8-1-2012
Abstract
OBJECTIVE: The objective of this study was to compare the efficacy of 3 doses of intranasal ketamine (INK) for sedation of children from 1 to 7 years old requiring laceration repair. METHODS: This was a randomized, prospective, double-blind trial of children requiring sedation for laceration repair. Patients with simple lacerations were randomized by age to receive 3, 6, or 9 mg/kg INK. Adequacy and efficacy of sedation were measured with the Ramsay sedation score and the Observational Scale of Behavioral Distress-Revised. Serum ketamine and norketamine levels were drawn during the procedure. Sedation duration and adverse events were recorded. RESULTS: Of the 12 patients enrolled, 3 patients achieved adequate sedation, all at the 9-mg/kg dose. The study was suspended at that time as per predetermined criteria. CONCLUSIONS: Nine milligrams of INK per kilogram produced a significantly higher proportion of successful sedations than the 3- and 6-mg/kg doses. Copyright © 2012 by Lippincott Williams & Wilkins.
Publication Title, e.g., Journal
Pediatric Emergency Care
Volume
28
Issue
8
Citation/Publisher Attribution
Tsze, Daniel S., Dale W. Steele, Jason T. MacHan, Fatemeh Akhlaghi, and James G. Linakis. "Intranasal ketamine for procedural sedation in pediatric laceration repair: A preliminary report." Pediatric Emergency Care 28, 8 (2012). doi: 10.1097/PEC.0b013e3182624935.