Document Type
Article
Date of Original Version
8-7-2013
Department
Biomedical and Pharmaceutical Sciences
Abstract
A number of cyclic peptides, including [FR]4, [FK]4, [WR]4, [CR]4, [AK]4, and [WK]n (n = 3-5) containing L-amino acids were synthesized using solid-phase peptide synthesis. We hypothesized that an optimal balance of hydrophobicity and charge could generate self-assembled nanostructures in aqueous solution by intramolecular and/or intermolecular interactions. Among all the designed peptides, [WR]n (n = 3-5) generated self-assembled vesicle-like nanostructures at room temperature as shown by Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and/or Dynamic light scattering (DLS). This class of peptides represents the first report of surfactant-like cyclic peptides that self-assemble into nanostructures. A plausible mechanistic insight of self-assembly of [WR]5 was investigated by molecular modeling studies. Modified [WR]5 analogues, such as [WMeR]5. [WR(Me)2]5, [WMeR(Me)2]5,and [WdR]5 exhibited different morphologies than [WR]5 as shown by TEM observations. [WR]5 exhibited significant stabilizing effect for generated silver nanoparticles and glyceraldehyde-3-phosphate dehydrogenase activity. These studies established a new class of surfactant-like cyclic peptides that self-assembled into nanostructures and could have potential applications for stabilizing of silver nanoparticles and protein biomolecules.
Citation/Publisher Attribution
Mandal, D., Tiwari, R.K., Shirazi, A.N., Oh, D., Ye, G., Banerjee, A., Yadav, A., & Parang, K. (2013). Self-assembled surfactant cyclic peptide nanostructures as stabilizing agents. Royal Society of Chemistry, 9(39). doi: 10.1039/C3SM50764E
Available at: http://dx.doi.org/10.1039/C3SM50764E
Author Manuscript
This is a pre-publication author manuscript of the final, published article.
Terms of Use
This article is made available under the terms and conditions applicable
towards Open Access Policy Articles, as set forth in our Terms of Use.