Document Type
Article
Date of Original Version
2012
Department
Biomedical and Pharmaceutical Sciences
Abstract
Designing microbicidal gels of anti-HIV drugs for local application to prevent HIV infection is a subject of major interest. 3′-Fluoro-3′-deoxythymidine (FLT), a nucleoside reverse transcriptase inhibitor (NRTI), was conjugated with a N-myristoylglutamate scaffold. The conjugate showed gelation at 1% (w/w) in different organic solvents, such as toluene, dichloromethane, and chloroform. The gels were opaque and stable at room temperature. The results indicate that myristoyl glutamate derivative of FLT can form an organogel. The gel could have potential application as a topical anti-HIV microbicidal agent.
Citation/Publisher Attribution
Chhikara, B. S., Tiwari, R., & Parang, K. (2012). N-Myristoylglutamic acid derivative of 3′-fluoro-3′-deoxythymidine as an organogel. Tetrahedron Letters, 53(39), 5335-5337. doi: 10.1016/j.tetlet.2012.07.101
Available at: https://doi.org/10.1016/j.tetlet.2012.07.101
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