Publications from the Department of Biomedical and Pharmaceutical Sciences faculty at the University of Rhode Island.

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Submissions from 2018

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DNA Base Sequence Effects on Bulky Lesion-Induced Conformational Heterogeneity during DNA Replication, Ang Cai, Katie A. Wilson, Satyakam Panaik, Stacey D. Wetmore, and Bongsup P. Cho

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Augmentation of Vaccine-induced Humoral and Cellular Immunity by a Physical Radiofrequency Adjuvant, Yan Cao, Xiaoyue Zhu, Md Nazir Hossen, Prateek Kakar, Yiwen Zhao, and Xinyuan Chen

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Levodopa-Reduced Mucuna pruriens Seed Extract Shows Neuroprotective Effects against Parkinson’s Disease in Murine Microglia and Human Neuroblastoma Cells, Caenorhabditis elegans, and Drosophila melanogaster, Shelby L. Johnson, Hyun Y. Park, Nicholas A. DaSilva, Dhiraj A. Vattem, Hang Ma, and Navindra P. Seeram

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Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effect, Hang Ma, Shelby L. Johnson, Weixi Lu, Nicholas A. DaSilva, Susan Meschwitz, Joel A. Dain, and Navindra P. Seeram

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Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1T, Qihao Wu, Robert W. Deering, Gaiyun Zhang, Bixia Wang, Xin Li, Jiadong Sun, Jianwei Chen, Huawei Zhang, David C. Rowley, and Hong Wang

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Nanoparticle Anchoring Targets Immune Agonists to Tumors Enabling Anti-Cancer Immunity Without Systemic Toxicity, Yuan Zhang, Na Li, Heikyung Suh, and Darrel J. Irvine

Submissions from 2017

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Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii, Matthew Bertin, Alexandre Roduit, Jiadong Sun, Gabriella Alves, Christopher Via, Miguel Gonzalez, Paul V. Zimba, and Peter D. R. Moeller

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Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom, Matthew Bertin, Paul G. Wahome, Paul V. Zimba, Haiyin He, and Peter D. R. Moeller

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Thymoquinone Ameliorates Diabetic Phenotype in Diet-Induced Obesity Mice via Activation of SIRT-1-Dependent Pathways, Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela Slitt, and Emma Heart

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Impact of Consuming ‘Toxic’ Monarch Caterpillars on Adult Chinese Mantid Mass Gain and Fecundity, Jamie Rafter, Liahna Gonda-King, Daniel Niesen, Navindra Seeram, Chad Rigsby, and Evan Preisser

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Differential Feedback Regulation of Δ4-3- Oxosteroid 5β-Reductase Expression by Bile Acids, Leila Valanejad, Christina Nadolny, Stephanie Shiffka, Yuan Chen, Sangmin You, and Ruitang Deng

Submissions from 2016

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Rhizoleucinoside, a Rhamnolipid–Amino Alcohol Hybrid from the Rhizobial Symbiont Bradyrhizobium sp. BTAi1, Jianwei Chen, Jiandong Sun, Robert W. Deering, Navindra P. Seeram, Hong Wang, and David C. Rowley

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N-Acyl Dehydrotyrosines, Typrosinase Inhibitors from the Marine Bacteriu, Thalasssotalea sp. PP2-459, Robert W. Deering, Jianwei Chen, Jiadong Sun, Hang Ma, Javier Dubert, Juan L. Barja, Navindra P. Seeram, Hong Wang, and David C. Rowley

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Developmental Lead Exposure and Lifespan Alterations in Epigenetic Regulators and their Correspondence to Biomarkers of Alzheimer's Disease, Aseel Eid, Syed Waseem Bihaqi, William Renehan, and Nasser H. Zawia

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Contributions of Tropodithietic Acid and Biofilm Formation to the Probiotic Activity of Phaeobacter Inhibens, Marta Gomez-Chiarri, D C. Rowley, and David R. Nelson

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The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice, Jaryse C. Harris, Joseph M. Martinez, Petar N. Grozdanov, Susan E. Bergeson, Paula Grammas, and Clinton C. MacDonald

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A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi, Elizabeth L. Harvey, Robert W. Deering, D. C. Rowley, Abrahim El Gamal, Michelle Schorn, Bradley Moore, Matthew Johnson, Tracy J. Mincer, and Kristen E. Whalen

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Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency, Benjamin Hilton, Sathyaraj Gopal, Lifang Xu, Sharmistha Mazumder, Phillip R. Musich, Bongsup P. Cho, and Yue Zou

Submissions from 2015

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Draft Genome Sequence of the Shellfish Larval Probiotic Bacillus pumilus RI06-95, Meagan Hamblin, Edward Spinard, Marta Gomez-Chiarri, David R. Nelson, and David C. Rowley

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The Cranberry Flavonoids PAC DP-9 and Quercetin Aglycone Induce Cytotoxicity and Cell Cycle Arrest and Increase Cisplatin Sensitivity in Ovarian Cancer Cells, Yifei Wang, Alex Han, Eva Chen, Rakesh K. Singh, Clinton O. Chichester, Richard G. Moore, Ajay P. Singh, and Nicholi Vorsa

Submissions from 2014

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Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities, Abdulrahman I. Almansour, Raju Suresh Kumar, Farzana Beevi, Amir Nasrolahi Shirazi, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Brian Sullivan, Kellen McCaffrey, Alaa Nahhas, Keykavous Parang, and Mohamed Ashraf Ali

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Lactate Dehydrogenase Like Crystallin: A Potentially Protective Shield for Indian Spiny-Tailed Lizard (Uromastyx hardwickii) Lens Against Environmental Stress?, Ambreen Atta, Amber Ilyas, Zehra Hashim, Aftab Ahmed, and Shamshad Zarina

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Clinical Implication of Changes in Serum Adiponectin in Patients with Hepatogenic Diabetes, Zhongying Bao, Xiaodong Yuan, Shuhong Duan, and Xiaoqun Dong

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Synthesis and Evaluation of c-Src Kinase Inhibitory Activity of Pyridin-2(1H)-one Derivatives, Karam Chand, Suchita Prasad, Rakesh K. Tiwari, Amir N. Shirazi, Sumit Kumar, Keykavous Parang, and Sunil K. Sharma

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Tea Polyphenols Induced Apoptosis of Breast Cancer Cells by Suppressing the Expression of Survivin, Xuesong Chen, Yu Li, Qiushi Lin, Yan Wang, Hong Sun, Jian Wang, Guoquan Cui, Li Cai, and Xiaoqun Dong

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Baseline Staging Tests Based on Molecular Subtype is Necessary for Newly Diagnosed Breast Cancer, Xuesong Chen, Lichun Sun, Yingying Cong, Tingting Zhang, Qiushi Lin, Qingwei Meng, Hui Pang, Yanbin Zhao, Yu Li, Li Cai, and Xiaoqun Dong

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Aspartate β-Hydroxylase Expression Promotes a Malignant Pancreatic Cellular Phenotype, Xiaoqun Dong, Qiushi Lin, Arihiro Aihara, Yu Li, Chiung-Kuei Huang, Waihong Chung, Qi Tang, Xuesong Chen, Rolf Carlson, Christina Nadolny, Gregory Gabriel, Mark Olsen, and Jack Wands

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Biomarkers of TGF-b Signaling Pathway and Prognosis of Pancreatic Cancer, Milind Javle, Yanan Li, Dongfeng Tan, Xiaoqun Dong, Ping Chang, Siddhartha Kar, and Donghui Li

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Self-Assembly of Peptides to Nanostructures, Dindyal Mandal, Amir Nasrolahi Shirazi, and Keykavous Parang

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Vibrio vulnificus MO6-24/O LipopolysaccharideStimulates Superoxide Anion, Thromboxane B2, Matrix Metalloproteinase-9, Cytokine and Chemokine Release by Rat Brain Microglia in Vitro, Alejandro M. S. Mayer, Mary L. Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, and Jan Powell

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Vibrio vulnificus MO6-24/O Lipopolysaccharide Stimulates Superoxide Anion, Thromboxane B2, Matrix Metalloproteinase-9, Cytokine and Chemokine Release by Rat Brain Microglia in Vitro, Alejandro M.S. Mayer, Mary L. Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, and Jan Powell

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Synthesis and Evaluation of Cytotoxic Activity of Substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides, Somayeh Motavallizadeh, Asal Asal Fallah-Taftia, Saeedeh Maleki, Amir Nasrolahi Shirazi, Mahboobeh Pordeli, Maliheh Safavi, Sussan Kabudanian Ardestani, Shaaban Asd, Rakesh Tiwari, Donghoon Oh, Abbas Shafiee, Alireza Foroumadi, Keykavous Parang, and Tahmineh Akbarzadeh

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Synthesis and Biological Evaluation of 5′-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors, Bhanu Pemmaraju, Hitesh K. Agarwal, Donghoon Oh, Karen W. Buckheit, Robert W. Buckheit Jr., Rakesh Tiwari, and Keykavous Parang

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A Polymorphic Microdeletion in the RGS9 Gene Suppresses PTB Binding and Associates with Obesity, Chong Shen, Meenakshi Sharma, Daniel C. Reid, Pengtao Li, Jeremy Celver, Norhashimah Abu Seman, Jinfeng Chen, Senthil K. Vasan, Hairu Wang, Tianwei Gu, Ying Liu, Wan Nazaimoon Wan Mohamud, Hongbing Shen, Kerstin Brismar, William G. Fairbrother, Abraham Kovoor, and Harvest F. Gu

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Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer, Jin Wang, Massimo Raimondo, Sushovan Guha, Jinyun Chen, Lixia Diao, Xiaoqun Dong, Michael B. Wallace, Ann M. Killary, Marsha L. Frazier, Timothy A. Woodward, Jing Wang, and Subrata Sen

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rs744166 Polymorphism of the STAT3 Gene is Associated with Risk of Gastric Cancer in a Chinese Population, Kevin Yuan, Huimin Liu, Lina Huang, Xiyun Ren, Jingjing Liu, Xiaoqun Dong, Wenjing Tian, and Yunhe Jia

Submissions from 2013

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Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents, Dindyal Mandal, Rakesh K. Tiwari, Amir Nasrolahi Shirazi, Donghoon Oh, Guofeng Ye, Antara Banarjee, Arpita Yadav, and Keykavous Parang

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A Simple and Efficient Synthesis of 2,3-Diarylnaphthofurans using Sequential Hydroarylation/Heck Oxyarylation, V. Kameshwara Rao, Gamesh M. Shelke, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Copper(II) triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities, V. Kameshwara Rao, Rakesh Tiwari, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Keykavous Parang, and Anil Kumar

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Cellular and Organismal Toxicity of the Anti-Cancer Small Molecule, Tolfenamic Acid: A Pre-Clinical Evaluation, Umesh T. Sankpal, Chris M. Lee, Sarah F. Connelly, Omer Kayaleh, Don Eslin, Robert Sutphin, Steven Goodison, Lina Adwan, Nasser H. Zawia, Lenard M. Lichtenberger, and Riyaz Basha

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Peptide-Amphiphile Containing Arginine and Fatty Acyl Chains as Molecular Transporters, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Kumar Tiwari, Brian Sullivan, Anju Gupta, Geoffrey D. Bothun, and Keykavous Parang

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Efficient Delivery of Cell Impermeable Phosphopeptides by a Cyclic Peptide Amphiphile Containing Tryptophan and Arginine, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Donghoon Oh, Antara Banarjee, Arpita Yadav, and Keykavous Parang

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Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue, Jialin Xu, Ajay C. Donepudi, Jamie E. Moscovitz, and Angela L. Slitt

Submissions from 2012

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Pharmacy Research at URI: Bile Acids and Bile Salt Export Pump: Physiology and Pathology, Ruitang Deng

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In vitro Transdermal Permeation of Fenoterol Hydrobromide, Ahmed H. Elshafeey, Yassin E. Hamza, Soad Y. Amin, and Hossein Zia

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Strong Association Between Two Polymorphisms on 15q25.1 and Lung Cancer Risk: A Meta-Analysis, Mingliang Gu, Xiaoqun Dong, Xuezhi Zhang, Xumin Wang, Yue Qi, Jun Yu, and Wenquan Niu

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Synergistic Association of PTGS2 and CYP2E1 Genetic Polymorphisms with Lung Cancer Risk in Northeastern Chinese, Shujie Guo, Xiaobo Li, Min Gao, Hong Kong, Yuqiong Li, Mingliang Gu, Xiaoqun Dong, and Wenquan Niu

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Unusual Sequence Effects on Nucleotide Excision Repair of Arylamine Lesions: DNA Bending/Distortion as a Primary Recognition Factor, Vipin Jain, Benjamin Hilton, Bin Lin, Satyakam Patnaik, Fengting Liang, Eva Darian, Yue Zou, Alexander D. MacKerell Jr., and Bongsup P. Cho

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Conformational and Thermodynamic Properties Modulate the Nucleotide Excision Repair of 2-aminofluorene and 2-acetylaminofluorene dGadducts in the NarI Sequence, Vipin Jain, Benjamin Hilton, Satyakam Patnaik, Yue Zou, M. Paul Chiarelli, and Bongsup P. Cho

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Nanoparticles for Cancer Treatment, Wei Lu

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Severe Diabetes and Leptin Resistance Cause Differential Hepatic and Renal Transporter Expression in Mice, Vijay More, Xia Wen, Paul E. Thomas, Lauren M. Aleksunes, and Angela L. Slitt

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Quantitative Analysis of Some Important Metals and Metalloids in Tobacco Products by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Syed Ghulam Musharraf, Muhammad Shoaib, Amna Jabbar Siddiqui, Muhammad Najam-ul-Haq, and Aftab Ahmed

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4-Aryl-4H-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation of Src Kinase Inhibitory and Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Deendayal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, and Tahmineh Akbarzadeh

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Pharmacy Research at URI: Mining Red Maple (Acer rubrum) Trees for Novel Therapeutics to Manage Diabetes, Navindra P. Seeram, Jialin Xu, Liya Li, and Angela L. Slitt

Submissions from 2011

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Substituted Coumarin Derivatives: Synthesis and Evaluation of Antiproliferative and Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, and Sunil K. Sharma

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Molecular Characterization of Novel Sulfotransferases from the Tick, Ixodes scapularis, Sivakamasundari Pichu, Roberta S. King, Emine Bihter Yalcin, José MC Ribeiro, and Thomas Mather

Submissions from 2009

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Influence of Flanking Sequence Context on the Conformational Flexibility of Aminofluorene-Modified dG Adduct in dA Mismatch DNA Duplexes, Nidhi Jain, Srinivasarao Meneni, Vipin Jain, and Bongsup P. Cho

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Secondary Metabolites Produced by the Marine Bacterium Halobacillus salinus That Inhibit Quorum Sensing-Controlled Phenotypes in Gram-Negative Bacteria, Margaret E. Teasdale, Jianyuan Liu, Joselynn Wallace, Fatemeh Akhlaghi, and David C. Rowley

Submissions from 2008

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DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence, Yingjuan Qian, Jin Zhang, Bingfang Yan, and Xinbin Chen

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Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression, Xiulong Song, Rajani Kaimal, Bingfang Yan, and Ruitang Deng

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Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD, Jinfang Wu, Md. Riyaz Basha, Brian Brock, David P. Cox, Fernando Cardozo-Pelaez, Christopher A. McPherson, Jean Harry, Deborah C. Rise, Brian Maloney, Demaio Chen, Debomoy K. Lahiri, and Nasser H. Zawia

Submissions from 2007

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Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event, Rasha Bhandari, Adolfo Saiardi, Yousef Ahmadibeni, Adele M. Snowman, Adam C. Resnick, Troels Z. Kristiansen, Henrik Molina, Akhilesh Pandey, J. Kent Werner Jr., Krishna R. Juluri, Yong Xu, Glenn D. Prestwich, Keykavous Parang, and Solomon H. Snyder

Submissions from 2006

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Cooperation between MEF2 and PPARγ in Human Intestinal β,β-Carotene 15,15'-Monooxygenase Gene Expression, Xiaoming Gong, Shu-Whei Tsai, Bingfang Yan, and Lewis P. Rubin

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Docking-based Substrate Recognition by the Catalytic Domain of a Protein Tyrosine Kinase, C-terminal Src Kinase (Csk), Sungsoo Lee, Marina K. Ayrapetov, David J. Kemble, Keykavous Parang, and Gongqin Sun

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Sequence effects of aminofluorene-modified DNA duplexes: thermodynamic and circular dichroism properties, Srinivasa Rao Meneni, Rhijuta D'Mello, Gregory Norigian, Gregory Baker, Lin Gao, M. Paul Chiarelli, and Bongsup P. Cho

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Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells, Changlin Zhou, Lihua Qiu, Yun Sun, Sarah Healey, Harold Wanebo, Nicola Kouttab, Wen Di, Bingfang Yan, and Yinsheng Wan

Submissions from 2005

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Plasma Clearance of Lovastatin Versus Chinese Red Yeast Rice in Healthy Volunteers, Zhaoping Li, Navindra P. Seeram, Rupo Lee, Gail Thames, Chayo Minutti, He-Jing Wang, and David Heber

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Antagonistic Interactions among Marine Bacteria Impede the Proliferation of Vibrio cholerae, Richard A. Long, David C. Rowley, Eric Zamora, Jiayuan Liu, Douglas H. Bartlett, and Farooq Azam

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The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain, M. Riyaz Basha, Wei Wei, Saleh A. Bakheet, Nathalie Benitez, Hasan K. Siddiqi, Yuan-Wen Ge, Debomoy K. Lahiri, and Nasser H. Zawia

Submissions from 2004

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Inhibitors of Protein Kinase Signaling Pathways : Emerging Therapies for Cardiovascular Disease, Thomas Force MD, Keisuke Kuida MD, Mark Namchuk PhD, Keykavous Parang PhD, and John M. Kyriakis PhD

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Synthesis and spectroscopic characterization of some chromanochalcones and their dihydro derivatives, M. Srinivasa Rao, J. Kotesh, R. Narukulla, and H. Duddeck

Submissions from 2003

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DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter, Yuxin Li, Mingxing Xie, Xiulong Song, Sarah Gragen, Karuna Sachdeva, Yinsheng Wan, and Bingfang Yan

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Relationship between reproductive success and male plasma vitellogenin concentrations in cunner, Tautogolabrus adspersus, Lesley J. Mills, Ruth E. Gutjahr-Gobell, Doranne Borsay Horowitz, Nancy D. Denslow, Marjorie C. Chow, and Gerald E. Zaroogian

Submissions from 2000

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A Population Pharmacokinetic Analysis of Nelfinavir Mesylate in Human Immunodeficiency Virus-Infected Patients Enrolled in a Phase III Clinical Trial, Kimberly A. Jackson, Sara E. Rosenbaum, Bradley M. Kerr, Yazdi K. Pithavala, Geoffrey Yuen, and Michael N. Dudley

Submissions from 1998

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In Vitro Anti-Hepatitis B Virus Activities of 5’-O-Myristoyl Analogue Derivatives of 3’-Fluoro-2’,3’-dideoxythymidine (FLT) and 3’-Azido-2’,3’- dideoxythymidine (AZT), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus, Jyy-Shiang Huang, and David L. Tyrrell

Submissions from 1995

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Metal Transport in Cells: Cadmium Uptake by Rat Hepatocytes and Renal Cortical Epithelial Cells, Zahir A. Shaikh, Mark E. Blazka, and Tetsuya Endo

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Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine., Victor Skita, David W. Chester, Carey J. Oliver, Joe G. Turcotte, and Robert H. Notter

Submissions from 1994

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Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D, Modechai Liscovitch, Vered Chalifa, Paolo Pertile, Ching-Shih Chen, and Lewis C. Cantley

Submissions from 1993

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Purification and Characterization of Novel “2-Arylpropionyl-CoA Epimerases” from Rat Liver Cytosol and Mitochondria, Woan-Ru Shieh and Ching-Shih Chen

Submissions from 1982

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Recent Progress in Marine Toxin Rsearch, Yuzuru Shimizu