Title
Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa
Document Type
Article
Date of Original Version
1-1-2021
Abstract
Two unusual di-isopentenyl guanidine alkaloids, named celosiadines A (1) and B (2), were isolated from Iresine diffusa aerial parts. The structures of the compounds were elucidated from extensive spectroscopic analyses including HRMS, NMR and ECD. Celosiadines A and B showed favorable binding affinity to the androgen receptor (AR) in silico and were cytotoxic towards AR-sensitive (LNCaP) but not AR-insensitive (PC3) human prostate cancer cells in vitro.
Publication Title, e.g., Journal
Natural Product Research
Volume
36
Issue
1
Citation/Publisher Attribution
Killian, Caroline, Shelby L. Johnson, Hang Ma, Brendan McKeown, Luke McDougall, Robert Hurta, Yongqiang Liu, and Navindra P. Seeram. "Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa." Natural Product Research 36, 1 (2021): 356-360. doi: 10.1080/14786419.2020.1784174.