Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa

Authors

Caroline Killian, University of Rhode Island
Shelby L. Johnson, University of Rhode Island
Hang Ma, University of Rhode Island
Brendan McKeown, University of Prince Edward Island
Luke McDougall, University of Prince Edward Island
Robert Hurta, University of Prince Edward Island
Yongqiang Liu, University of Rhode Island
Navindra P. Seeram, University of Rhode Island

Document Type

Article

Date of Original Version

1-1-2021

Abstract

Two unusual di-isopentenyl guanidine alkaloids, named celosiadines A (1) and B (2), were isolated from Iresine diffusa aerial parts. The structures of the compounds were elucidated from extensive spectroscopic analyses including HRMS, NMR and ECD. Celosiadines A and B showed favorable binding affinity to the androgen receptor (AR) in silico and were cytotoxic towards AR-sensitive (LNCaP) but not AR-insensitive (PC3) human prostate cancer cells in vitro.

Publication Title, e.g., Journal

Natural Product Research

Volume

36

Issue

1

Citation/Publisher Attribution

Killian, Caroline, Shelby L. Johnson, Hang Ma, Brendan McKeown, Luke McDougall, Robert Hurta, Yongqiang Liu, and Navindra P. Seeram. "Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa." Natural Product Research 36, 1 (2021): 356-360. doi: 10.1080/14786419.2020.1784174.