Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice
Document Type
Article
Date of Original Version
1-1-2021
Abstract
Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit extract (PE) was investigated for its hepatoprotective and anti-inflammatory effects in male C57BL/6 mice fed either a high-fat diet or a standard rodent diet with or without 1% of PE for 12 weeks. Mouse livers and hippocampi were evaluated for the expression of genes associated with NAFLD and inflammation by multiplexed gene analysis. PE alleviated diet-induced fatty liver and suppressed hepatic lipid regulating genes including Cd36, Fas, Acot2 and Slc27a1. In addition, PE suppressed gene expression of pro-inflammatory cytokines including Il-1α, Il-7, Il-11, Ifnα, Tnfα and Lepr in the hippocampi. Our findings support the protective effects of PE against high-fat diet-induced hepatic and neurological disease.
Publication Title, e.g., Journal
International Journal of Food Sciences and Nutrition
Volume
72
Issue
4
Citation/Publisher Attribution
Pfohl, Marisa, Nicholas A. DaSilva, Emily Marques, Juliana Agudelo, Chang Liu, Michael Goedken, Angela L. Slitt, Navindra P. Seeram, and Hang Ma. "Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice." International Journal of Food Sciences and Nutrition 72, 4 (2021): 499-510. doi: 10.1080/09637486.2020.1849041.