Relationship between leucine oxidation and oxygen consumption during steady-state exercise
Document Type
Article
Date of Original Version
1-1-2001
Abstract
Purpose: The purpose of this study was to assess the relationship between whole-body leucine oxidation and oxygen consumption during steady-state exercise. Our hypothesis was that leucine oxidation will be responsive to increased whole-body energy needs. Methods: Sixteen healthy individuals (7 women and 9 men) were infused with a stable isotope of leucine and, for comparison purposes, lysine during 60 min of moderate-intensity exercise. Results: Leucine oxidation was increased (P < 0.05) and nonoxidative leucine disposal was decreased (P < 0.05), whereas leucine and lysine rate of appearance remained unchanged (P = NS) during exercise. Linear regression analysis indicated a modest relationship between leucine oxidation and steady-state oxygen consumption (R = 0.69; P < 0.003) during steady-state exercise. The coefficient of determination (R2 = 0.49) indicates that approximately half of the variance in whole-body leucine oxidation during exercise can be explained by whole-body oxygen consumption. Conclusion: In a statistically appropriate sample size of humans whose dietary intake was controlled, the whole-body rate of leucine oxidation during exercise was only partially influenced by energy demands.
Publication Title, e.g., Journal
Medicine and Science in Sports and Exercise
Volume
33
Issue
2
Citation/Publisher Attribution
Lamont, L. S., A. J. McCullough, and S. C. Kalhan. "Relationship between leucine oxidation and oxygen consumption during steady-state exercise." Medicine and Science in Sports and Exercise 33, 2 (2001): 237-241. doi: 10.1097/00005768-200102000-00011.