Electric fields in hippocampus due to transcranial focal electrical stimulation via concentric ring electrodes
Document Type
Conference Proceeding
Date of Original Version
12-26-2011
Abstract
As epilepsy affects approximately one percent of the world population, electrical stimulation of brain has recently shown potential as an additive seizure control therapy. In this study we applied focal transcranial electrical stimulation (TFS) on the surface of the skull of rats via concentric ring electrodes. We recorded electric potentials with a bipolar electrode consisting of two stainless steel wires implanted into the left ventral hippocampus. TFS current was gradually increased by 20% starting at 103 A allowing us to assess the relationship between TFS current and both potentials recorded from the bipolar electrode and the resulting electric field. Generally, increases in TFS current resulted in increases in the electric field. This allows us to estimate what extra-cranial TFS current would be sufficient to cause the activation of neurons in the hippocampus. © 2011 IEEE.
Publication Title, e.g., Journal
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS
Citation/Publisher Attribution
Besio, Walter G., Ruba Hadidi, Oleksandr Makeyev, Hiram Luna-Munguía, and Luisa Rocha. "Electric fields in hippocampus due to transcranial focal electrical stimulation via concentric ring electrodes." Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS (2011). doi: 10.1109/IEMBS.2011.6091400.