The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma
Date of Original Version
Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo. Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.
Shi, Lei, Pei Liu, Jing Wu, Lun Ma, Han Zheng, Michael P. Antosh, Haiyan Zhang, Bo Wang, Wei Chen, and Xiuli Wang. "The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma." Nanomedicine 14, 15 (2019): 2027-2043. doi:10.2217/nnm-2019-0094.