The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma

Authors

Lei Shi, Tongji University
Pei Liu, Tongji University
Jing Wu, University of Rhode Island
Lun Ma, The University of Texas at Arlington
Han Zheng, The University of Texas at Arlington
Michael P. Antosh, University of Rhode Island
Haiyan Zhang, Tongji University
Bo Wang, Tongji University
Wei Chen, The University of Texas at Arlington
Xiuli Wang, Tongji University

Document Type

Article

Date of Original Version

1-1-2019

Abstract

Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo. Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.

Publication Title, e.g., Journal

Nanomedicine

Volume

14

Issue

15

Citation/Publisher Attribution

Shi, Lei, Pei Liu, Jing Wu, Lun Ma, Han Zheng, Michael P. Antosh, Haiyan Zhang, Bo Wang, Wei Chen, and Xiuli Wang. "The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma." Nanomedicine 14, 15 (2019): 2027-2043. doi: 10.2217/nnm-2019-0094.