X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors
Document Type
Article
Date of Original Version
8-20-2019
Abstract
Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray–induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide–conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.
Publication Title, e.g., Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
116
Issue
34
Citation/Publisher Attribution
Shrestha, Samana, Jing Wu, Bindeshwar Sah, Adam Vanasse, Leon N. Cooper, Lun Ma, Gen Li, Huibin Zheng, Wei Chen, and Michael P. Antosh. "X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors." Proceedings of the National Academy of Sciences of the United States of America 116, 34 (2019): 16823-16828. doi: 10.1073/pnas.1900502116.