X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors
Date of Original Version
Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray–induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide–conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.
Proceedings of the National Academy of Sciences of the United States of America
Shrestha, Samana, Jing Wu, Bindeshwar Sah, Adam Vanasse, Leon N. Cooper, Lun Ma, Gen Li, Huibin Zheng, Wei Chen, and Michael P. Antosh. "X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors." Proceedings of the National Academy of Sciences of the United States of America 116, 34 (2019): 16823-16828. doi:10.1073/pnas.1900502116.