Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter
Date of Original Version
The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT. This journal is
Organic and Biomolecular Chemistry
Naumiec, Gregory R., Grace Lincourt, Jeremy P. Clever, Michael A. McGregor, Abraham Kovoor, and Brenton Deboef. "Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter." Organic and Biomolecular Chemistry 13, 9 (2015): 2537-2540. doi:10.1039/c4ob02165g.