Explore master's theses and doctoral dissertations from graduates of the URI Department of Biomedical and Pharmaceutical Sciences.

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Theses/Dissertations from 2024

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A C-MET RECEPTOR TARGETING NANOPARTICLE PLATFORM FOR COMBINATION THERAPY AGAINST HEPATOCELLULAR CARCINOMA, Subarna Das

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MECHANISTIC APPROACH TO UNDERSTANDING ADVERSE LIVER OUTCOMES RELATED TO PFAS EXPOSURE IN NEONATAL AND ADULT MICE, Emily Kaye

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USING BLOOD BIOMARKERS TO PREDICT PRECLINICAL ALZHEIMER’S DISEASE, Haley Leclerc

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DEVELOPING EFFECTIVE PHYSICAL AND CHEMICAL ADJUVANTS FOR INFLUENZA AND TUMOR VACCINES, Yibo Li

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MECHANISTIC AND TOXICOKINETIC ANALYSIS OF PERFLUOROALKYL SUBSTANCES: PROTEOMICS APPROACH AND THE ROLE OF FATTY ACID BINDING (FABP), Seyed Mohamad Sadegh Modaresi

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DNA DAMAGE, MODIFICATION AND REPAIR, Xianhao Zhou

Theses/Dissertations from 2023

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UNDERLYING MECHANISMS OF UBIQUITIN SPECIFIC PEPTIDASE 2 ISOFORMS REGULATION IN HEPATOCELLULAR CARCINOMA BY THE FARNESOID X RECEPTOR SIGNALING PATHWAY, Winifer M. Ali

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13C LABELING FOR CHO CELL METABOLISM TRACING AND MS BASED ANALYSIS FOR ADVANCED UPSTREAM CULTURE MONITORING TO SUPPORT CQA UNDERSTANDING, Xin Bush

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A STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIPS OF CARCINOGENIC PROTEIN- AND DNA-BINDING CHEMICALS, Alicia M. Crisalli

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MECHANISMS OF PPAR-ALPHA TARGETED THERAPY IN CHOLESTASIS: TRANSLATIONAL STUDIES, Gina Gallucci

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ENHANCING THE EFFICACY OF INHALABLE NANOPARTICLE FORMULATIONS USING BIOMIMETIC LUNG SURFACTANT, Andrea Jennifer Gonsalves

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OPIOIDS AND OPIOID USE DISORDER TREATMENT IN PREGNANCY: SPONTANEOUS ABORTION AND CHILDHOOD NEURODEVELOPMENTAL DISORDERS, Mennatullah Hasan

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CHOOSING WISELY IN PROPHYLACTIC NEUROKININ-1 RECEPTOR ANTAGONIST USE AMONG WOMEN WITH BREAST CANCER: A RETROSPECTIVE COHORT STUDY, Shweta Kamat

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REAL-WORLD MEDICATION MANAGEMENT OF INDIVIDUALS WITH SICKLE CELL DISEASE, Abiodun John Ologunowa

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EVALUATION OF THE TOXICOKINETIC MECHANISMS OF PERFLUOROALKYL SUBSTANCES: ACCUMULATION, DISTRIBUTION, AND ELIMINATION, Sangwoo Ryu

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CHILDREN’S OUTCOMES AND MATERNAL OPIOID EXPOSURES DURING PREGNANCY, Shuang Wang

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DEVELOPMENT OF LOCALIZED DRUG DELIVERY STRATEGIES FOR THE TREATMENT OF CANCERS AND INFECTIOUS DISEASES, Weizhou Yue

Theses/Dissertations from 2022

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TREPROSTINIL, A PROSTACYCLIN ANALOG, PROTECTS KIDNEY FROM RENAL ISCHEMIA-REPERFUSION INJURY: PRECLINICAL STUDIES IN A RAT MODEL OF ACUTE KIDNEY INJURY, Meiwen Ding

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THE MECHANISTIC AND ETIOLOGICAL LINK BETWEEN BILE ACID DYSREGULATION AND PRETERM BIRTH, Syed Fayaz Ul Haq Hashmi

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TREPROSTINIL IMPROVES HEPATIC CYTOCHROME P450 METABOLISM DURING RENAL ISCHEMIA REPERFUSION INJURY, Daniel Kelly

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PREDICTORS OF EPI PROCOLON UTILIZATION, Eric Lamy

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AN EVALUATION OF THE EFFECTIVENESS AND SAFETY OF DIRECT ORAL ANTICOAGULANTS VERSUS WARFARIN IN CHRONIC LIVER DISEASE, AND AFTER ANTICOAGULANT-RELATED MAJOR BLEEDING, Oluwadolapo D. Lawal

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CHEMICAL BIOLOGY OF DNA ADDUCT REPAIR, BYPASS AND MUTAGENESIS, Rui Qi

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CHEMICAL INVESTIGATION OF METABOLITES PRODUCED BY MARINE PSEUDOALTEROMONAS SPP., Margaret Rosario

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A PROTEOMIC APPROACH TO UNDERSTANDING REGULATORY PATHWAYS IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), Teresa Sierra

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IMPACTS OF HYPERTENSION AND THROMBOSIS IN A RAT MODEL OF CEREBRAL AMYLOID ANGIOPATHY (rTg-DI), Aleksandra Stanisavljevic

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PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL EVALUATION OF MAPLE (Acer saccharum) SAP WATER, Kara Torrey

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TRANSLATION AND VALIDATION OF MYELOID DERIVED SUPPRESSOR CELL PROTEOMIC TARGETS IN LIVER AND LUNG TUMORS, Justin Trickett

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A MULTI-YEAR INVESTIGATION OF THE SPECIALIZED METABOLITE COMPOSITION OF TRICHODESMIUM SPP., Christopher William Via

Theses/Dissertations from 2021

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SEVERAL FACTORS AND THEIR ROLE IN CONTROL OF LEPIDOPTERA POPULATIONS, Alex K. Baranowski

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PHARMACIST-ADMINISTERED PEDIATRIC INFLUENZA VACCINATION IN THE UNITED STATES, Dana M. Gates

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DUAL-DRUG NANOPARTICLE FORMULATION FOR INHALED DELIVERY IN IDIOPATHIC PULMONARY FIBROSIS TREATMENT, Moez Ghumman

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INVESTIGATING TOLFENAMIC ACID AND ITS ANALOGS AS POTENTIAL ALZHEIMER’S DISEASE THERAPEUTICS, Jaunetta Hill

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HEPATOPROTECTIVE EFFECTS OF TREPROSTINIL DURING RENAL ISCHEMIA-REPERFUSION INJURY, Joyce Hou

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EVALUATING NATURAL PRODUCT LIBRARIES WITH EMPHASIS ON IN VITRO PERMEABILITY WORKFLOWS, Riley D. Kirk

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ANTI-INFLAMMATORY EFFECTS OF POLYPHENOL-ENRICHED EXTRACTS, Chang Liu

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REAL-WORLD UTILIZATION AND EXPENDITURE OF TOP-DOWN AND STEP-UP THERAPY IN INFLAMMATORY BOWEL DISEASE, Kanya K. Shah

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EVALUATION OF MEDICATIONS FOR OPIOID USE DISORDER ON OVERDOSE AND HEALTHCARE UTILIZATION IN THE US, Tianyu Sun

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SELF-ADJUVANTED VIRUS-LIKE PARTICLE FOR SAFE AND HIGHLY IMMUNOGENIC VACCINATION, Yiwen Zhao

Theses/Dissertations from 2020

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PERFLUOROOCTANESULFONIC ACID (PFOS) AS A POTENTIAL RISK FACTOR FOR LATE-ONSET ALZHEIMER’S DISEASE, Veronia Basaly

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THE COMPARATIVE EFFECTIVENESS, SAFETY, AND COST OF ORAL P2Y12 ANTIPLATELET AGENTS FOLLOWING ACUTE CORONARY SYNDROMES, Nicholas Belviso

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PRESCRIPTION CONTROLLED SUBSTANCE UTILIZATION: EVALUATING BENZODIAZEPINE DOSE INTENSITY, DEVELOPMENT AND APPLICATION OF A MEASUREMENT FRAMEWORK, AND USE OF TRAMADOL AMONG PATIENTS WITH HIGHER RISK, Eric P. Borrelli

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CHEMICAL INVESTIGATION OF BACTERIAL INTERACTIONS INVOLVING PATHOGENS, Hilary Joan Grant Ranson

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EVALUATION OF KEY PERFLUOROALKYL SUBSTANCES TO INDUCE LIVER STEATOSIS IN MOUSE AND HUMAN MODELS, Emily Sara Marques

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CHEMICAL INVESTIGATIONS OF PECTIC OLIGOSACCHARIDES FROM VACCINIUM MACROCARPON, Zhiyuan Peng

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DRUG-INDUCED LIVER INJURY: A PREDICTIVE MODEL, MITOCHONDRIAL TOXICITY MECHANISMS RISK, AND ANTIPSYCHOTIC MEDICATIONS RISK IN A REAL-WORLD SETTING, Payal Rana

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EVALUATION OF THE RELATIONSHIP BETWEEN CENTRALITY AND INDIVIDUAL-LEVEL CHARACTERISTICS AMONG PWID, Benjamin Skov

Theses/Dissertations from 2019

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COMPARATIVE EFFECTS OF TOLFENAMIC ACID AND DONEPEZIL ON BEHAVIOR AND TAU PATHOLOGY BIOMARKER LEVELS, Abdullah G. Alharbi

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POLYPHARMACY IN CANCER PATIENTS: HEALTH-RELATED QUALITY OF LIFE, EXPENDITURES, AND ADVERSE EVENTS, Zachary R. Babcock

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USE OF HYPHENATED MASS SPECTROMETRY TO UNCOVER TRUE NAFLD EFFECT ON HUMAN DRUG DISPOSITION PROTEINS, Benjamin Joseph Barlock

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DNA damage, repair and mutational spectrum, Ke Bian

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ANTI-INFLAMMATORY EFFECTS OF POLYPHENOL-ENRICHED EXTRACTS AND THEIR GUT MICROBIAL METABOLITES, Nicholas A. DaSilva

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BUDGET IMPACT ANALYSIS OF NOVEL ABUSE DETERRENT OPIOID FORMULATIONS IN A POPULATION OF CHRONIC OPIOID USE, Andrew Descoteaux

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DEVELOPMENT OF PEDIATRIC ANTI-HIV FORMULATIONS WITH IMPROVED DISSOLUTION CHARACTERISTICS, Ryan Ivone

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LASER-ASSISTED TRANSDERMAL DRUG DELIVERY AND VACCINATION, Prateek Kakar

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SHORT-TERM COST-EFFECTIVENESS OF SECOND-GENERATION LONG-ACTING INJECTABLE ANTIPSYCHOTICS AS COMPARED WITH ORAL ANTIPSYCHOTICS IN PREVENTING REHOSPITALIZATION OR TREATMENT SWITCH IN PATIENTS WITH SCHIZOPHRENIA, Tyler Mantaian

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AN ‘OMICS APPROACH TO DIET & STRUCTURE IMPACT ON PERFLUOROALKYL SUBSTANCE INDUCED LIVER DISEASE, Marisa Pfohl

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AN OMICS BASED APPROACH FOR THE IDENTIFICATION OF BIOMARKERS IN NON-ALCOHOLIC FATTY LIVER DISEASE USING IN VITRO MODELS OF HEPATIC STEATOSIS, Anitha Saravanakumar

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OVERCOMING CONTEMPORARY OBSTACLES IN DRUG DELIVERY VIA ACETALATED DEXTRAN PARTICLE FORMULATIONS, Nishan K. Shah

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CHEMICAL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF METHYLATION AND GLYCATION DNA ADDUCTS, Qi Tang

Theses/Dissertations from 2018

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EXPRESSION AND ACTIVITY OF CYP2C8 AND 2C9 IN DIABETES MELLITUS AND NONALCOHOLIC FATTY LIVER DISEASE, Ghadah Alghaith

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Economic Burden and Mortality Associated With Prescription Opioid Use, Hilary A. Aroke

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MECHANISMS OF INDIVIDUAL VARIATION IN GLUCURONIDATION, SULFONATION, AND AMIDATION: BISPHENOL A AND BILE ACIDS, Adam Michael Auclair

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Phytochemical Investigation of a Native North American Species, “Acer saccarinum” and an Endemic Saudi Arabian Species, “Euphorbia saudiarabica, Abdullatif Bin Muhsinah

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In Vitro Drug Metabolism and Population Pharmacokinetics as Tools for Elucidating Pharmacokinetic Variability, Enoch Cobbina

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An Evaluation of Atypical Antipsychotic Use, Costs and Effectiveness in the Pediatric Population, Kellye A. Donovan

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THE BIOLOGICAL FUNCTION OF HUMAN EPIDIDYMIS PROTEIN 4 IN EPITHELIAL OVARIAN CANCER, Nicole Elizabeth James

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EFFECT OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) ON HEPATIC DRUG METABOLISM ENZYMES IN HUMAN, Rohitash Jamwal

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REGULATION OF UBIQUITIN SPECIFIC PEPTIDASE 2 EXPRESSION BY FARNESOID X RECEPTOR IN HEPATOCELLULAR CARCINOMA, Christina Nadolny

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Influence of Environmental Factors and Fishing Effort on Demersal Fish Species in Ghana, Vida Samantha Osei

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Predictors of Concomitant Use of Prescription Opiods and Benzodiazepines in Rhode Island, Emily Patry

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EFFECT OF ETHANOL ON GASTROINTESTINAL TIGHT JUNCTIONS AND P-GLYCOPROTEIN EXPRESSION AND FUNCTIONALITY, Armin Sadighi

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Facilitated Excretion of Gold Nanoparticles by Copper Sulfide Nanoparticles Through the ATP7B Transporter, Xiaodong Wang

Theses/Dissertations from 2017

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Biotransformation and Pharmacokinetic Evaluation of PF-5190457, A Novel Drug Candidate for Alcoholism, Sravani Adusumalli

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The Physiological Glucagon Receptor in Rat Heart, Kevin Agostinucci

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Concomitant Use of Central Nervous System Stimulants and Depressants Prescribed in Rhode Island, Aram Babcock

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Health Outcomes Research of Novel Disease Modifying Medications in Alzheimer’s Disease and Cost Burden of Early Onset Dementia, Rami Beiram

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Conformational Insights Into Aminobiphenyl-Modified DNA: Implications for Mutation and Repair, Ang Cai

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Using Natural Products to Treat Resistant and Persistent Bacterial Infections, Robert W. Deering

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Predictors of Infection in Rheumatoid Arthritis Patients Using Anti-Tumor Necrosis Factor Agents, Tasia Liu

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Circadian Rhythm: A Functional Connection Between SHP and DEC1 Transcription Factor, Marek Matczynski Marczak

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Novel Pharmacological Action of Clozapine at D2 Dopamine Receptors, Joseph Michael Schrader

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CES Involved Inhibition and Regulation, Yuanjun Shen

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Novel Methods for Delivering and Promoting the Endosomal Escape of Nucleic Acid Based Drugs: Chiral Polyamines and Hydrophobic Nanoparticle-Containing Liposomes, Ruchi Verma

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Flavin-Containing Monooxygenase-3 and 5: Tissue Distribution, Age-Related Expression and Regulation by Endoplasmic Reticulum Stress, Zhen Xu

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Cardiovascular Adverse Events in Patients Receiveing QT Interval Prolonging Medications, Yizhou Ye

Theses/Dissertations from 2016

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Effect of Disease State on Human Carboxylesterase 1 Expression and Activity, Abdullah Aljutayli

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Healthcare Costs and Impact of Medication Adherence on Outcomes in Patients on Novel Anticoagulant Therapy, Chinmay Deshpande

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A Study of the Increased Risk of Bleeding Events in Patients with Blood Clotting Disorders, Associated with Antidepressant Medication Use, Adam Ehrenborg

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Retrospective Cohort Study of Tobacco Dependence Treatment Patterns in a US Commercially Insured Population, Elizabeth Anne MacLean

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Factors Associated With Sustained Release Psychostimulant Prescriptions for Pediatric ADHD, Robert McConeghy

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Isolation, Synthesis, and Metabolism of Polyphenols: Stilbenoids, Gallotannins and Ellagitannins, Daniel B. Niesen

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Antimicrobial Resistance Patterns and Protective Effects of Statins in Bacteremic Patients, Ajinkya Pawar

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Investigations on Biologically Active Carbohydrates from Natural Sources, Jiadong Sun

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Measuring Adherence with Antidepressant Medication: Comparison of HEDIS and PDC Methodologies, Carmen Monica Telinoiu

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Cadmium Contributes to Breast Cancer Development by Influencing Cell Adhesion Network, Zhengxi Wei

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Bile Acids and Premature Labor in Intrahepatic Cholestasis of Pregnancy, Sangmin You

Theses/Dissertations from 2015

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A Cross-Sectional Analysis of Bronchodilator Prescribing in COPD and Cardiovascular Comorbidity, Damilola Tejumola Adesanoye

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NRF as an Oxidative Stress and Nutrient Responsive Transcription Factor in Calorie Restriction, Laura Armstrong

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Synthesis of 2-Amino-α-Carboline and Analogues Relevant for Structural Investigations of the Corresponding DNA Adducts, Matthew S. Blake