Uncovering Orthologous Genes of the Ciona Intestinalis Fanconi Anemia Pathway

Author

Edward Stanley, University of Rhode IslandFollow

Date of Award

2015

Degree Type

Thesis

Degree Name

Master of Science in Biological and Environmental Sciences (MSBES)

Department

Biological Sciences

First Advisor

Steven Irvine

Abstract

Fanconi Anemia is a disease caused by any number of mutations in a collection of DNA double-strand repair genes. In silico tests were performed to determine whether any of these genes were conserved in Ciona, which split from humans over 500 million years ago. Among the 22 gene products tested, evidence for 10 orthologs were discovered. Possible orthologs were seen in all three of the major groups of FA proteins.

Recommended Citation

Stanley, Edward, "Uncovering Orthologous Genes of the Ciona Intestinalis Fanconi Anemia Pathway" (2015). Open Access Master's Theses. Paper 475.
https://digitalcommons.uri.edu/theses/475