Date of Award
2024
Degree Type
Thesis
Degree Name
Master of Science in Chemical Engineering (MSChE)
Department
Chemical Engineering
First Advisor
Daniel Roxbury
Abstract
This thesis investigates the creation of core-shell nanofibers for enhanced wound healing applications using a variety of polymer combinations. Chronic wounds are a major worry in the biomedical sector, and researchers are looking at new materials to help the healing process. The PVDF/PVA core-shell structure with single-walled carbon nanotubes (SWCNTs) was chosen due to its balanced mechanical strength, high biocompatibility, and DNA-SWCNT complex stability. PVDF is a preferred shell material due to its biocompatibility and water solubility, making it excellent for wound dressings, implanted scaffolds, and sensors that monitor healing.
The study focuses on improving the electrospinning method to produce homogeneous aligned microfibers with the optimum structure and properties for wound monitoring, specifically hydrogen peroxide. The detection of hydrogen peroxide relies on the fluorescence modulation of encapsulated GT15-ssDNA SWCNTs. PVDF/PVA-SWCNT core-shell nanofibers were characterized, and they demonstrated good structural and functional properties for wound healing. XRD study identified the β-phase of PVDF, whereas FTIR proved the presence of PVDF in the shell. Raman spectroscopy confirmed the successful integration of PVDF, PVA, and SWCNTs into the fibers. Peaks at 510 and 840 cm-1 indicate the β-phase of PVDF, while peaks at 548 and 1130 cm-1 correspond to PVA. SWCNTs exhibited RBM peaks and a graphitic structure, indicating good integration of these elements into the fibers.
The results indicate that these smart fabrics have a promising structure, characteristics, and biological performance. Next-generation wound care materials produced as a result of developments in materials science and nanotechnology have the potential to significantly improve patient outcomes.
Recommended Citation
Chowdhury, Devleena, "DEVELOPING SMART TEXTILES ENCAPSULATED WITH SINGLE WALLED CARBON NANOTUBES FOR BIOMEDICAL APPLICATIONS" (2024). Open Access Master's Theses. Paper 2583.
https://digitalcommons.uri.edu/theses/2583