Date of Award
1967
Degree Type
Thesis
Degree Name
Master of Science in Pharmacy
Department
Pharmacy
First Advisor
James C. Price
Abstract
The effects of granule density and bulk density on tablet weight, weight variation, and tablet density were determined for tablets compressed on a Colton Model 216, rotary tablet press. Hardness, thickness, and disintegration times were also determined for the tablets produced. Standardized granulations were made from lactose and mixtures of lactose and bismuth subcarbonate, with gelatin as a binder. Granule density and bulk density of the granulations were varied by changing the concentrations of bismuth aubcarbonate in the formula. All tablets were made at a fixed rate of tableting using standardized settings of the fill, pressure, and overload adjustments. The interrelationship between granule density and bulk density was found to be almost linear, as was also the relationship between granule density, bulk density, and tablet weight.
Recommended Citation
Bhandari, Amritkumar, "The Interrelationship of Bulk Density, Granule Density, Tablet Weight, and Weight Variation" (1967). Open Access Master's Theses. Paper 180.
https://digitalcommons.uri.edu/theses/180
Terms of Use
All rights reserved under copyright.