Major
Microbiology
Minor(s)
Italian
Advisor
Ramsey, Kathryn, M
Advisor Department
Cell and Molecular Biology
Date
4-2020
Keywords
genome; Next-Generation Sequencing; computational analysis; virulence
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Abstract
Francisella noatunensis subs. orientalis is a known fish pathogen that has been most notably isolated from tilapia (Oreochromis niloticus) in Costa Rica. The genome of this Francisella species pathogen has been sequenced using Next-Generation Sequencing and been made available for the scientific community. Dr. Kathryn Ramsey’s research laboratory in the Department of Cell and Molecular Biology at the University of Rhode Island works with several Francisella species pathogens and is interested in identifying the differences, if any, between the known genome sequence of Francisella noatunensis and that of a laboratory isolate of the same species. With the use of computational genetic analysis techniques, we are specifically interested in distinguishing any genetic differences relevant to the organism’s growth requirements and/or pathogenesis. This information will be helpful in cultivating the organism, as well as provide some insight into how similar our laboratory isolate is to Francisella noatunensis that has been isolated from the environment.