Protection of dogs from lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21
Document Type
Article
Date of Original Version
1-1-1995
Abstract
A vaccine consisting of purified Escherichia coli-expressed recombinant full-length outer surface proteins A (OspA) and B (OspB) and the saponin adjuvant QS21 was evaluated for protection against Borrelia burgdorferi infection. Eleven beagles were vaccinated twice and then challenged with 10 field-collected adult female Ixodes scapularis. Xenodiagnosis revealed that all 11 nonvaccinated control dogs and 2 of 10 vaccinated dogs were infected with B. burgdorferi. Six of 11 control dogs also developed fever (0.75 ± 0.38°C) and were lethargic. One of the control dogs also developed a limp. Both of the infected vaccinated dogs were asymptomatic. Thus, the vaccine prevented tick-vectored infection and associated symptoms of Lyme disease. © 1995, by The University of Chicago.
Publication Title, e.g., Journal
Journal of Infectious Diseases
Volume
171
Issue
4
Citation/Publisher Attribution
Coughlin, Richard T., Durland Fish, Thomas N. Mather, Jianneng Ma, Charles Pavia, and Patrice Bulger. "Protection of dogs from lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21." Journal of Infectious Diseases 171, 4 (1995). doi: 10.1093/infdis/171.4.1049.