Title
Ixodes scapularis: Salivary kininase activity is a metallo dipeptidyl carboxypeptidase
Document Type
Article
Date of Original Version
1-1-1998
Abstract
Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment 1-7 and 1-5 as being produced subsequent to incubation of purified salivary kininase with bradykinin. The activity was inhibited by captopril and EDTA and was activated by cobalt and manganese, a behavior similar to that displayed by angiotensin-converting enzymes of vertebrate and invertebrate origins.
Publication Title, e.g., Journal
Experimental Parasitology
Volume
89
Issue
2
Citation/Publisher Attribution
Ribeiro, José M.C., and Thomas N. Mather. "Ixodes scapularis: Salivary kininase activity is a metallo dipeptidyl carboxypeptidase." Experimental Parasitology 89, 2 (1998). doi: 10.1006/expr.1998.4296.