Document Type
Article
Date of Original Version
4-28-2020
Department
Physics
Abstract
The advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other approaches are emerging. In this discussion, we examine the use of cell surface acidity as a feature that can be exploited by using pH-sensitive peptide folding to target agents to diseased cell surfaces or cytoplasms.
Citation/Publisher Attribution
Reshetnyak YK, Moshnikova A, Andreev OA and Engelman DM (2020) Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding. Front. Bioeng. Biotechnol. 8:335. doi: 10.3389/fbioe.2020.00335
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.