Ampicillin in Combination with Ceftaroline, Cefepime, or Ceftriaxone Demonstrates Equivalent Activities in a High-Inoculum Enterococcus faecalis Infection Model

Authors

Megan K. Luther, University of Rhode Island
B. Rice
Kerry L. LaPlante, University of Rhode IslandFollow

Document Type

Article

Date of Original Version

2016

Department

Pharmacy Practice

Abstract

Ampicillin-ceftriaxone combination therapy has become a predominant treatment for serious Enterococcus faecalis infections, such as endocarditis. Unfortunately, ceftriaxone use is associated with future vancomycin-resistant enterococcus colonization. We evaluated E. faecalis in an in vitro pharmacodynamic model against simulated human concentration-time profiles of ampicillin plus ceftaroline, cefepime, ceftriaxone, or gentamicin. Ampicillin-cefepime and ampicillin-ceftaroline demonstrated activities similar to those of ampicillin-ceftriaxone against E. faecalis.

Citation/Publisher Attribution

Luther MK, Rice LB, LaPlante KL. 2016. Ampicillin in combination with ceftaroline, cefepime, or ceftriaxone demonstrates equivalent activities in a highinoculum Enterococcus faecalis infection model. Antimicrob Agents Chemother 60:3178 –3182. doi: 10.1128/AAC.03126-15.

Available at: http://dx.doi.org/10.1128/AAC.03126-15