Date of Original Version
In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.
LaPlante, K. L., & Sakoulas, G. (2009). Evaluating Aztreonam and Ceftazidime Pharmacodynamics with Escherichia coli in Combination with Daptomycin, Linezolid, or Vancomycin in an In Vitro Pharmacodynamic Model. Antimicrobial Agents and Chemotherapy, 53(10), 4549-4555. doi: 10.1128/AAC.00180-09
Available at: http://dx.doi.org/10.1128/AAC.00180-09