In Vitro Activities of Telavancin and Vancomycin against Biofilm-Producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis Strains

Authors

Kerry L. LaPlante, University of Rhode IslandFollow
A. Mermel

Document Type

Article

Date of Original Version

2009

Department

Pharmacy Practice

Abstract

We investigated the activities of telavancin and vancomycin against biofilm-producing Staphylococcus and Enterococcus strains. At clinically attainable concentrations, telavancin was active against bacteria embedded in biofilm (minimal biofilm eradication concentration [MBEC], 0.125 to 2 μg/ml) and inhibited biofilm formation at concentrations below the MIC. Vancomycin did not demonstrate the same activity (MBEC, ≥512 μg/ml) against Staphylococcus aureus and Enterococcus faecalis. Telavancin may have a unique role in biofilm-associated infections.

Citation/Publisher Attribution

LaPlante, K. L., & Mermel, L. A. (2009). In Vitro Activities of Telavancin and Vancomycin against Biofilm-Producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis Strains. Antimicrobial Agents and Chemotherapy, 53(7), 3166-3169. doi: 10.1128/AAC.01642-08

Available at: http://dx.doi.org/10.1128/AAC.01642-08