Effects of CPTA upon carotenogenesis and lipoidal constituents in Rhodotorula species
Date of Original Version
The effects of 2-(4-chlorophenyl)-triethylamine (CPTA) upon carotenogenesis in Rhodotorula glutinis, and upon various lipoidal constituents of R. rubra were studied. CPTA was found to cause the accumulation of lycopene and γ-carotene and to inhibit the formation of fatty acids and ergosterol. Upon removal of the inhibitor lycopene was metabolized to the cyclic carotenes and the levels of ergosterol increased. It was proposed that CPTA inhibits the cyclase enzyme of carotenogenesis, inhibits the formation of ergosterol, and causes the build-up of intermediates of these compounds. © 1974.
Hayman, Ernest, Clinton O. Chichester, and Kenneth L. Simpson. "Effects of CPTA upon carotenogenesis and lipoidal constituents in Rhodotorula species." Phytochemistry 13, 7 (1974): 1123-1127. doi:10.1016/0031-9422(74)80085-3.