Influence of Medium and Method on the In Vitro Susceptibility of Pseudomonas aeruginosa and Other Bacteria to Ciprofloxacin and Enoxacin

Authors

Jürg Blaser
N. Dudley, University of Rhode Island
Deborah Gilbert, University of Rhode Island
Stephen H. Zinner, University of Rhode Island

Document Type

Article

Date of Original Version

1986

Department

Pharmacy Practice

Abstract

Ciprofloxacin and enoxacin were two- to fourfold less active against Pseudomonas aeruginosa in calcium- and magnesium-supplemented broth compared with unsupplemented broth regardless of inoculum size, presence of serum, or use of inhibitory or bactericidal endpoints (P < 0.01). The effect of cation supplementation was less pronounced and less consistent for Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus.

Citation/Publisher Attribution

Blaser, J., Dudley, M. N., Gilbert, D., & Zinner, S. H. (1986). Influence of Medium and Method on the In Vitro Susceptibility of Pseudomonas aeruginosa and Other Bacteria to Ciprofloxacin and Enoxacin. Antimicrob. Agents Chemother., 29(5), 927-929. doi: 10.1128/AAC.29.5.92.

Available at: http://dx.doi.org/10.1128/AAC.29.5.927