Effect of Protein Binding on Drug Penetration into Blister Fluid

Authors

Wen Chyi Shyu
Quintiliani
Charles H. Nightingale
Michael N. Dudley, University of Rhode Island

Document Type

Article

Date of Original Version

1988

Department

Pharmacy Practice

Abstract

The effect of protein binding on drug penetration into blister fluid was evaluated by using cefonicid, ceftizoxime, and cefotaxime. Drug concentrations in a chamber with a high surface area/volume ratio (i.e., paper disk) follow changes in serum more closely than do those in a chamber with a low surface area/volume ratio. Both the area under the concentration-time curve ratio and the concentration ratio (by the disk method) for cefonicid were statistically lower than the ratios for ceftizoxime and cefotaxime. The high degree of protein binding of cefonicid results in the availability of less drug for diffusion to blister fluid than with the low-protein-binding ceftizoxime and cefotaxime.

Citation/Publisher Attribution

Shyu, W. C., Quintiliani, R., Nightingale, C. H., & Dudley, M. N. (1988). Effect of Protein Binding on Drug Penetration into Blister Fluid. Antimicrob. Agents Chemother., 32(1), 128-130. doi: 10.1128/AAC.32.1.128.

Available at: http://dx.doi.org/10.1128/AAC.32.1.128