Altered Theophylline Metabolism in Patients with Psoriasis

Authors

Dennis P. West
H. Fischer, University of Illinois at Chicago
Marilyn McFarland Barbour, University of Rhode Island
Michael J. Cwik, University of Illinois at Chicago
Giuseppe Micali, Università degli Studi di Catania
Virginia C. Fiedler, Pfizer Inc.

Document Type

Article

Date of Original Version

1-1-1990

Abstract

We observed two patients on theophylline therapy with concomitant severe psoriasis and a two- to threefold greater theophylline clearance than that reported in healthy, nonsmoking adults. There were no factors known to induce theophylline clearance. In both cases, the induction of theophylline metabolism was relatively selective for the 1-methyluric acid pathway. The altered metabolism in these patients appeared to correlate with the clinical severity of the disease. The data suggest the possibility that an observed lack of efficacy for theophylline in psoriasis may be related to pharmacokinetic effects. The concept that altered drug metabolism may occur in the presence of skin disease has important implications for pharmacotherapeutics in dermatology. © 1990, SAGE Publications. All rights reserved.

Publication Title, e.g., Journal

Annals of Pharmacotherapy

Volume

24

Issue

5

Citation/Publisher Attribution

West, Dennis P., H. Fischer, Marilyn M. Barbour, Michael J. Cwik, Giuseppe Micali, and Virginia C. Fiedler. "Altered Theophylline Metabolism in Patients with Psoriasis." Annals of Pharmacotherapy 24, 5 (1990): 464-467. doi: 10.1177/106002809002400503.