Title

In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus

Document Type

Article

Date of Original Version

9-1-2010

Abstract

We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 ± 0.17 log10 CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 ± 0.26 log10 CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus. © 2010 Elsevier Inc.

Publication Title

Diagnostic Microbiology and Infectious Disease

Volume

68

Issue

1

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