In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus
Document Type
Article
Date of Original Version
9-1-2010
Abstract
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 ± 0.17 log10 CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 ± 0.26 log10 CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus. © 2010 Elsevier Inc.
Publication Title, e.g., Journal
Diagnostic Microbiology and Infectious Disease
Volume
68
Issue
1
Citation/Publisher Attribution
McConeghy, Kevin W., and L. LaPlante. "In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus." Diagnostic Microbiology and Infectious Disease 68, 1 (2010): 1-6. doi: 10.1016/j.diagmicrobio.2010.04.011.