Title

Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis

Document Type

Article

Date of Original Version

3-1-2009

Abstract

Four echinomycin antibiotics were isolated from the culture broth of a marine streptomycete, and their structures were determined by a combination of chemical and spectroscopic analyses. Antibiotic activities were measured against drug-resistant and biofilm-forming strains of Staphylococcus aureus and Enterococcus faecalis. Minimum inhibitory concentrations ranging from 0.01 μM to greater than 14 μM clearly defined structure-activity relationships for antibiotic potency. Echinomycin was the most active compound with a MIC of 0.03 μM against methicillin-resistant S. aureus and 0.01 μM against biofilm-forming E. faecalis. © 2009 Elsevier Ltd. All rights reserved.

Publication Title

Bioorganic and Medicinal Chemistry Letters

Volume

19

Issue

5

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