Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis
Date of Original Version
Four echinomycin antibiotics were isolated from the culture broth of a marine streptomycete, and their structures were determined by a combination of chemical and spectroscopic analyses. Antibiotic activities were measured against drug-resistant and biofilm-forming strains of Staphylococcus aureus and Enterococcus faecalis. Minimum inhibitory concentrations ranging from 0.01 μM to greater than 14 μM clearly defined structure-activity relationships for antibiotic potency. Echinomycin was the most active compound with a MIC of 0.03 μM against methicillin-resistant S. aureus and 0.01 μM against biofilm-forming E. faecalis. © 2009 Elsevier Ltd. All rights reserved.
Bioorganic and Medicinal Chemistry Letters
Socha, Aaron M., Kerry L. LaPlante, David J. Russell, and David C. Rowley. "Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis." Bioorganic and Medicinal Chemistry Letters 19, 5 (2009): 1504-1507. doi:10.1016/j.bmcl.2009.01.010.