Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis

Authors

Aaron M. Socha, University of Rhode Island
L. LaPlante, University of Rhode Island
David J. Russell, Varian, Inc.
David C. Rowley, University of Rhode Island

Document Type

Article

Date of Original Version

3-1-2009

Abstract

Four echinomycin antibiotics were isolated from the culture broth of a marine streptomycete, and their structures were determined by a combination of chemical and spectroscopic analyses. Antibiotic activities were measured against drug-resistant and biofilm-forming strains of Staphylococcus aureus and Enterococcus faecalis. Minimum inhibitory concentrations ranging from 0.01 μM to greater than 14 μM clearly defined structure-activity relationships for antibiotic potency. Echinomycin was the most active compound with a MIC of 0.03 μM against methicillin-resistant S. aureus and 0.01 μM against biofilm-forming E. faecalis. © 2009 Elsevier Ltd. All rights reserved.

Publication Title, e.g., Journal

Bioorganic and Medicinal Chemistry Letters

Volume

19

Issue

5

Citation/Publisher Attribution

Socha, Aaron M., L. LaPlante, David J. Russell, and David C. Rowley. "Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis." Bioorganic and Medicinal Chemistry Letters 19, 5 (2009): 1504-1507. doi: 10.1016/j.bmcl.2009.01.010.