Date of Award
Doctor of Philosophy in Chemistry
Brenton L. DeBoef
The formation of carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds is discussed and efforts towards expanding the known reactions of this type are the primary focus of this work. The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes and furans has been achieved. The use of an imine directing group allowed for the ortho-functionalization of these heterocycles with complete conversation in 15 minutes at °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. C-N bond formation is achieved using aryl Grignard reagents and N-chloroamines at -78 °C.
Sirois, John Joseph, "Iron-Catalyzed Arylation of Heterocycles and Transition-Metal Free C-N Bond Formation" (2015). Open Access Dissertations. Paper 369.