Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping

Authors

Judith S. Mercer, University of Rhode IslandFollow
Betty R. Vohr
Debra A. Erickson-Owens, University of Rhode IslandFollow
James F. Padbury
William Oh

Document Type

Article

Date of Original Version

2010

Department

Nursing

Abstract

Objective: The results from our previous trial revealed that infants with delayed cord clamping (DCC) had significantly lesser intraventricular hemorrhage (IVH) and late-onset sepsis (LOS) than infants with immediate cord clamping (ICC). A priori, we hypothesized that infants with DCC would have better motor function by 7 months corrected age.

Study Design: Infants between 24 and 31 weeks were randomized to ICC or DCC and follow-up evaluation was completed at 7 months corrected age.

Result: We found no differences in the Bayley Scales of Infant Development (BSID) scores between the DCC and ICC groups. However, a regression model of effects of DCC on motor scores controlling for gestational age, IVH, bronchopulmonary dysplasia, sepsis and male gender suggested higher motor scores of male infants with DCC.

Conclusion: DCC at birth seems to be protective of very low birth weight male infants against motor disability at 7 months corrected age.

Citation/Publisher Attribution

Mercer, J. S., Vohr, B. R., Erickson-Owens, D. A., Padbury, J. F., & Oh, W. (2010). Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping. Journal of Perinatology, 30(1), 11-16. doi: 10.1038/jp.2009.170

Available at: https://doi.org/10.1038/jp.2009.170