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The gradients of elevations and latitudes in the Appalachian Mountains provide a unique regional perspective on landscape variations in the eastern United States and southeastern Canada. We reveal patterns and trends of landscape dynamics, land surface phenology, and ecosystem production along the Appalachian Mountains using time series data from Global Inventory Modeling and Mapping Studies and Advanced Very High Resolution Radiometer Global Production Efficiency Model datasets. We analyze the spatial and temporal patterns of the normalized difference vegetation index (NDVI), length of growing season (LOS), and net primary production (NPP) of selected ecoregions along the Appalachian Mountains regions. We compare the results in different spatial contexts, including North America and the Appalachian Trail corridor area. To reveal latitudinal variations, we analyze data and compare the results between the 30°-to-40°N and the 40°-to-50°N latitudes. The result reveal significant decreases in annual peak NDVI in the Appalachian Mountains regions. The trend for the Appalachian Mountains regions was a −0.0018 (R2=0.55, P<0.0001) NDVI unit decrease per year during 25 years from 1982 to 2006. The LOS was prolonged by 0.3  days per year−1 during the 25-year percent. The NPP increased by 2.68  g Cm−2 yr−2 from 1981 to 2000.