Title
Three dimensional simulation of dynamics and deformation of red blood cells in capillary flow
Document Type
Conference Proceeding
Date of Original Version
12-1-2010
Abstract
A three-dimensional computational model using dissipative particle dynamics (DPD) is developed to simulate dynamics and deformation of red cells (RBC) in capillaries. DPD is able to produce correct hydrodynamics of the flow and incorporate microscopic detail of various segments of the cell. RBC is constructed using DPD particles, which are connected by a spring network to represent the membrane. The total energy of the RBC is associated with the bending energy, in-plane shear energy and the constraints of fixed area and volume. Shape optimization of swollen RBC due to continuous deflation based on the minimum energy principle is conducted to obtain the biconcave shape in equilibrium. Then, an external force is applied to the cell to study the large deformation in axial and lateral direction and compared with the experimental results. Also, RBC is placed inside a 10 mm capillary flow to study the dynamics and deformation of the cell. The cell undergoes steady deformation and acquires parachute type shape as observed in experiments. Copyright © 2010 by ASME.
Publication Title, e.g., Journal
ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume
10
Citation/Publisher Attribution
Yamada, Toru, Anurag Kumar, Yutaka Asako, and Mohammad Faghri. "Three dimensional simulation of dynamics and deformation of red blood cells in capillary flow." ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) 10, (2010): 905-910. doi: 10.1115/IMECE2010-39140.