Influence of HMB supplementation and resistance training on cytokine responses to resistance exercise

Authors

William J. Kraemer, University of Connecticut
Disa L. Hatfield, University of Rhode Island
Brett A. Comstock, University of Connecticut
Maren S. Fragala, University of Central Florida
Patrick M. Davitt, University of Connecticut
Cristina Cortis, Universita di Cassino e del Lazio Meridionale
Jacob M. Wilson, The University of Tampa
Elaine C. Lee, University of Connecticut
Robert U. Newton, Edith Cowan University
Courtenay Dunn-Lewis, Merrimack College
Keijo Häkkinen, University of Jyväskylä
Tunde K. Szivak, University of Connecticut
David R. Hooper, University of Connecticut
Shawn D. Flanagan, University of Connecticut
David Looney, University of Connecticut
Mark T. White, University of Connecticut
Jeff S. Volek, University of Connecticut
Carl M. Maresh, University of Connecticut

Document Type

Article

Date of Original Version

8-20-2014

Abstract

Purpose: The purpose of this study was to determine the effects of a multinutritional supplement including amino acids, β-hydroxy-β-methylbutyrate (HMB), and carbohydrates on cytokine responses to resistance exercise and training. Methods: Seventeen healthy, college-aged men were randomly assigned to a Muscle Armor™ (MA; Abbott Nutrition, Columbus, OH) or placebo supplement group and 12 weeks of resistance training. An acute resistance exercise protocol was administered at 0, 6, and 12 weeks of training. Venous blood samples at pre-, immediately post-, and 30-minutes postexercise were analyzed via bead multiplex immunoassay for 17 cytokines. Results: After 12 weeks of training, the MA group exhibited decreased interferon-gamma (IFN-γ) and interleukin (IL)-10. IL-1β differed by group at various times. Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-7, IL-8, IL-12p70, IL-13, IL-17, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1β) changed over the 12-week training period but did not differ by group. Conclusions: Twelve weeks of resistance training alters the cytokine response to acute resistance exercise, and supplementation with HMB and amino acids appears to further augment this result.

Publication Title, e.g., Journal

Journal of the American College of Nutrition

Volume

33

Issue

4

Citation/Publisher Attribution

Kraemer, William J., Disa L. Hatfield, Brett A. Comstock, Maren S. Fragala, Patrick M. Davitt, Cristina Cortis, Jacob M. Wilson, Elaine C. Lee, Robert U. Newton, Courtenay Dunn-Lewis, Keijo Häkkinen, Tunde K. Szivak, David R. Hooper, Shawn D. Flanagan, David Looney, Mark T. White, Jeff S. Volek, and Carl M. Maresh. "Influence of HMB supplementation and resistance training on cytokine responses to resistance exercise." Journal of the American College of Nutrition 33, 4 (2014): 247-255. doi: 10.1080/07315724.2014.911669.