The effects of different exercise training modalities on plasma proenkephalin Peptide F in women

Authors

William DuPont, The Ohio State University
William Kraemer, The Ohio State University
Bradley Nindl, University of Pittsburgh
Elaine Lee, University of Connecticut
Maren Fragala, Quest Diagnostics Incorporated
Disa Hatfield, University of Rhode Island
Lydia Caldwell, The Ohio State University
Emily Post, The Ohio State University
Matthew Beeler, The Ohio State University
Jeff Volek, The Ohio State University
Carl Maresh, The Ohio State University

Document Type

Article

Date of Original Version

5-1-2017

Abstract

Due to the important interactions of proenkephalin fragments (e.g., proenkephalin [107–140] Peptide F) to enhance activation of immune cells and potentially combat pain associated with exercise-induced muscle tissue damage, we examined the differential plasma responses of Peptide F to different exercise training programs. Participants were tested pre-training (T1), and after 8 weeks (T2) of training. Fifty-nine healthy women were matched and then randomly assigned to one of four groups: heavy resistance strength training (STR, n = 18), high intensity endurance training (END, n = 14), combined strength and endurance training (CMB, n = 17), or control (CON, n = 10). Blood was collected using a cannula inserted into a superficial vein in the antecubital fossa with samples collected at rest and immediately after an acute bout of 6 X 10 RM in a squat resistance exercise before training and after training. Prior to any training, no significant differences were observed for any of the groups before or after acute exercise. With training, significant (P ≤ 0.95) elevations were observed with acute exercise in each of the exercise training groups and this effect was significantly greater in the CMB group. These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses. Such findings appear to indicate adrenal medullary adaptations opioid production significantly altered with exercise training.

Publication Title, e.g., Journal

Peptides

Volume

91

Citation/Publisher Attribution

DuPont, William, William Kraemer, Bradley Nindl, Elaine Lee, Maren Fragala, Disa Hatfield, Lydia Caldwell, Emily Post, Matthew Beeler, Jeff Volek, and Carl Maresh. "The effects of different exercise training modalities on plasma proenkephalin Peptide F in women." Peptides 91, (2017): 26-32. doi: 10.1016/j.peptides.2017.02.006.