Document Type
Article
Date of Original Version
12-5-2014
Abstract
Tuberculosis (TB) cellular immune responses were examined in breastmilk of HIV-infected mothers using the T-SPOT.TB interferon gamma release assay (IGRA). Positive TB IFN-γ responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breastmilk and blood assays, TB IFN- γ responses were higher in breastmilk compared to blood (p=.02). The magnitude of TB IFN-γ responses in maternal breastmilk and blood were correlated. Elucidating the influence of breastmilk TB immune responses on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.
Citation/Publisher Attribution
Cranmer, L.M. et al. "Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers." The International Journal of Tuberculosis and Lung Disease. December 5, 2014. Available: http://dx.doi.org/10.5588/ijtld.14.0384
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